Retrospective Review on Safety and Efficacy of Combination Biologic Therapy for Psoriasis.

IF 1.8 4区医学 Q2 DERMATOLOGY

Australasian Journal of Dermatology Pub Date : 2025-08-08 DOI:10.1111/ajd.14584

Nicole Kah Mun Yoong, Xin Lin Wong, John Sullivan

{"title":"Retrospective Review on Safety and Efficacy of Combination Biologic Therapy for Psoriasis.","authors":"Nicole Kah Mun Yoong, Xin Lin Wong, John Sullivan","doi":"10.1111/ajd.14584","DOIUrl":null,"url":null,"abstract":"Background: There is limited data on the use of dual or combination biologic therapy in dermatological patients, particularly in psoriasis or with other coexisting dermatological conditions. However, this may be necessary for a small proportion of patients.Methods: We conducted a retrospective review of 46 patients treated with dual or combination biologic therapy at a single dermatology practice in Sydney, Australia. The patient cohort consisted of 44 patients with psoriasis, 1 patient with hidradenitis suppurativa and 1 patient with a combination of hidradenitis suppurativa and psoriasis.Results: Of 46 patients receiving a combination of biological agents, only 1 experienced an adverse effect that did not require cessation of therapy.Conclusion: The use of combination biologic therapy may be an option for psoriasis patients with recalcitrant disease, in particular for those with concomitant psoriatic arthritis or other dermatological conditions. However, further studies are warranted to evaluate the efficacy, safety and health economics of this treatment approach.","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Australasian Journal of Dermatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/ajd.14584","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: There is limited data on the use of dual or combination biologic therapy in dermatological patients, particularly in psoriasis or with other coexisting dermatological conditions. However, this may be necessary for a small proportion of patients.

Methods: We conducted a retrospective review of 46 patients treated with dual or combination biologic therapy at a single dermatology practice in Sydney, Australia. The patient cohort consisted of 44 patients with psoriasis, 1 patient with hidradenitis suppurativa and 1 patient with a combination of hidradenitis suppurativa and psoriasis.

Results: Of 46 patients receiving a combination of biological agents, only 1 experienced an adverse effect that did not require cessation of therapy.

Conclusion: The use of combination biologic therapy may be an option for psoriasis patients with recalcitrant disease, in particular for those with concomitant psoriatic arthritis or other dermatological conditions. However, further studies are warranted to evaluate the efficacy, safety and health economics of this treatment approach.

查看原文本刊更多论文

银屑病联合生物治疗的安全性和有效性回顾性评价。

背景：在皮肤病患者，特别是银屑病或其他共存皮肤病患者中使用双重或联合生物治疗的数据有限。然而，这对一小部分患者可能是必要的。方法：我们对澳大利亚悉尼单一皮肤科诊所接受双重或联合生物治疗的46例患者进行了回顾性研究。患者队列包括44例银屑病患者、1例化脓性汗腺炎患者和1例化脓性汗腺炎合并银屑病患者。结果：在接受生物制剂联合治疗的46例患者中，只有1例出现了不需要停止治疗的不良反应。结论：对于顽固性银屑病患者，特别是伴有银屑病关节炎或其他皮肤病的患者，联合生物治疗可能是一种选择。然而，需要进一步的研究来评估这种治疗方法的有效性、安全性和健康经济性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Australasian Journal of Dermatology 医学-皮肤病学

CiteScore

3.20

自引率

5.00%

发文量

186

审稿时长

6-12 weeks

期刊介绍： Australasian Journal of Dermatology is the official journal of the Australasian College of Dermatologists and the New Zealand Dermatological Society, publishing peer-reviewed, original research articles, reviews and case reports dealing with all aspects of clinical practice and research in dermatology. Clinical presentations, medical and physical therapies and investigations, including dermatopathology and mycology, are covered. Short articles may be published under the headings ‘Signs, Syndromes and Diagnoses’, ‘Dermatopathology Presentation’, ‘Vignettes in Contact Dermatology’, ‘Surgery Corner’ or ‘Letters to the Editor’.