Evaluation of age effect on circulating catecholamines' network in pregnant mares.

IF 2 3区农林科学 Q2 VETERINARY SCIENCES

Veterinary Research Communications Pub Date : 2025-08-08 DOI:10.1007/s11259-025-10853-2

Katiuska Satué, Pietro Medica, Deborah La Fauci, Elena Damía Gímenez, Esterina Fazio

{"title":"Evaluation of age effect on circulating catecholamines' network in pregnant mares.","authors":"Katiuska Satué, Pietro Medica, Deborah La Fauci, Elena Damía Gímenez, Esterina Fazio","doi":"10.1007/s11259-025-10853-2","DOIUrl":null,"url":null,"abstract":"<p><p>Catecholamines (CATs) are essential neuroendocrine regulators with plasma concentrations that naturally fluctuate during pregnancy. Age-related changes in CATs, observed in humans and animals, suggest that gestation and aging together influence catecholaminergic activity. Blood samples were collected from Spanish Purebred mares categorized into three age cohorts (4-7 years, n = 18; 8-10 years, n = 18; 11-15 years, n = 18) across four defined gestational stages: first trimester (T1), second trimester (T2), third trimester (T3), and the final bimester (B4). Plasma concentrations of adrenaline (A), noradrenaline (NA), and dopamine (DA) were quantified using a horse-specific validated competitive enzyme immunoassay (3-CAT EIA). CATs during gestation showed age-dependent patterns: A declined from T1 to T2 (p < 0.05), stabilizing or slightly increasing at T3-B4; mares 8-10 years had greatest A at T1, while 11-15 years maintained greater A concentrations at T2. NA was elevated in younger mares (4-7 years) in late gestation (p ≤ 0.05), with the lowest concentrations in mares of 8-10 years. DA peaked in mid-gestation and decreased before parturition (p ≤ 0.05), with older mares that display a more stable profile. These findings highlight age-related modulation of neuroendocrine function during pregnancy.</p>","PeriodicalId":23690,"journal":{"name":"Veterinary Research Communications","volume":"49 5","pages":"277"},"PeriodicalIF":2.0000,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary Research Communications","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1007/s11259-025-10853-2","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Catecholamines (CATs) are essential neuroendocrine regulators with plasma concentrations that naturally fluctuate during pregnancy. Age-related changes in CATs, observed in humans and animals, suggest that gestation and aging together influence catecholaminergic activity. Blood samples were collected from Spanish Purebred mares categorized into three age cohorts (4-7 years, n = 18; 8-10 years, n = 18; 11-15 years, n = 18) across four defined gestational stages: first trimester (T1), second trimester (T2), third trimester (T3), and the final bimester (B4). Plasma concentrations of adrenaline (A), noradrenaline (NA), and dopamine (DA) were quantified using a horse-specific validated competitive enzyme immunoassay (3-CAT EIA). CATs during gestation showed age-dependent patterns: A declined from T1 to T2 (p < 0.05), stabilizing or slightly increasing at T3-B4; mares 8-10 years had greatest A at T1, while 11-15 years maintained greater A concentrations at T2. NA was elevated in younger mares (4-7 years) in late gestation (p ≤ 0.05), with the lowest concentrations in mares of 8-10 years. DA peaked in mid-gestation and decreased before parturition (p ≤ 0.05), with older mares that display a more stable profile. These findings highlight age-related modulation of neuroendocrine function during pregnancy.

查看原文本刊更多论文

年龄对妊娠母马循环儿茶酚胺网络影响的评价。

儿茶酚胺（CATs）是重要的神经内分泌调节剂，其血浆浓度在怀孕期间自然波动。在人类和动物中观察到的与年龄相关的cat变化表明，妊娠和衰老共同影响儿茶酚胺能活性。采集了西班牙纯种母马的血液样本，分为三个年龄组(4-7岁，n = 18；8-10年，n = 18；11-15岁，n = 18)，分为四个妊娠阶段：妊娠早期（T1）、妊娠中期（T2）、妊娠晚期（T3）和妊娠晚期（B4）。血浆中肾上腺素(A)、去甲肾上腺素（NA）和多巴胺（DA）的浓度采用马特异性的竞争性酶免疫分析法（3-CAT EIA）进行定量。妊娠期间的cat表现出年龄依赖性：A从T1到T2下降(p

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Veterinary Research Communications 农林科学-兽医学

CiteScore

2.50

自引率

0.00%

发文量

173

审稿时长

3 months

期刊介绍： Veterinary Research Communications publishes fully refereed research articles and topical reviews on all aspects of the veterinary sciences. Interdisciplinary articles are particularly encouraged, as are well argued reviews, even if they are somewhat controversial. The journal is an appropriate medium in which to publish new methods, newly described diseases and new pathological findings, as these are applied to animals. The material should be of international rather than local interest. As it deliberately seeks a wide coverage, Veterinary Research Communications provides its readers with a means of keeping abreast of current developments in the entire field of veterinary science.