Hye Jin Chang, Yoon Hee Cho, Yeong Sook Yoon, Younglim Kho, Je Yeon Lee, Dong Won Hwang, Jung Yeol Han, Jisun Lee, Young Ah Kim
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引用次数: 0
Abstract
Background: Prenatal exposure to phthalates is reported to influence fetal growth and may lead to lasting adverse effects on infants and their future development; yet, the results remain inconclusive.
Objective: This study utilized a birth cohort of 73 pregnant women-newborn pairs, including biological fathers (73 triads), to investigate the relationship between parental phthalate exposure during pregnancy and birth outcomes in newborns.
Methods: Demographic, behavioral, and clinical information, along with urine samples from both parents, were collected prior to delivery. Sixteen phthalate metabolites were quantified in urine samples.
Results: Significant correlations were observed between six phthalate metabolites (MEP, MiBP, MnBP, MBzP, MEHP, and 5cx-MEPP) in maternal urine and paternal levels. Maternal MBzP was positively associated with boys' birth weight, whereas maternal 2cx-MMHP was negatively associated with girls' birth weight. The ponderal index of boys was negatively related to maternal MBzP and MMP, but positively associated with ∑MEHP-3 and ∑MEHP-5 after adjusting for confounding variables. Among paternal phthalates, MBzP showed a negative association with boys' ponderal index, whereas MEP showed a positive association. Maternal MEOHP, ∑MEHP-3, and ∑MEHP-5 were positively associated with boys' placenta weight, while MEOHP, MEHHP, 5cx-MEPP, ∑MEHP-3, and ∑MEHP-5 were negatively associated with girls' placenta weight.
Conclusions: Our findings suggest that parental exposure to phthalates at birth may adversely affect fetal growth and placental development in neonates. However, further studies with larger sample sizes and datasets are necessary.
期刊介绍:
Drawing from a large number of disciplines, Reproductive Toxicology publishes timely, original research on the influence of chemical and physical agents on reproduction. Written by and for obstetricians, pediatricians, embryologists, teratologists, geneticists, toxicologists, andrologists, and others interested in detecting potential reproductive hazards, the journal is a forum for communication among researchers and practitioners. Articles focus on the application of in vitro, animal and clinical research to the practice of clinical medicine.
All aspects of reproduction are within the scope of Reproductive Toxicology, including the formation and maturation of male and female gametes, sexual function, the events surrounding the fusion of gametes and the development of the fertilized ovum, nourishment and transport of the conceptus within the genital tract, implantation, embryogenesis, intrauterine growth, placentation and placental function, parturition, lactation and neonatal survival. Adverse reproductive effects in males will be considered as significant as adverse effects occurring in females. To provide a balanced presentation of approaches, equal emphasis will be given to clinical and animal or in vitro work. Typical end points that will be studied by contributors include infertility, sexual dysfunction, spontaneous abortion, malformations, abnormal histogenesis, stillbirth, intrauterine growth retardation, prematurity, behavioral abnormalities, and perinatal mortality.