Non-tuberculous micobacteria in the elderly. Multicentric study.

IF 3.1 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Respiratory medicine Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI:10.1016/j.rmed.2025.108297

I Gonzalez-Munoz, M V Leal Arranz, J A Garcia Fuentes, B Santos Zorrozua, M Zuriarrain Alonso, L Altube Urrengoechea, J Ugedo Urruela, E Tabernero Huguet

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引用次数: 0

Abstract

Background: Nontuberculous mycobacterial (NTM) pulmonary disease is an increasingly common infectious condition that particularly affects patients with pre-existing lung disease, immunosuppression, and the elderly.

Objectives: To determine the incidence of NTM isolation and NTM pulmonary disease (NTM-PD) in older adults and describe their clinical, radiological characteristics, and treatment outcomes.

Methods: A multicenter observational study conducted retrospectively (2012-2017) and prospectively (2018-2020) in five tertiary hospitals in northern Spain. All adults aged ≥18 years with NTM isolation from respiratory samples were included and followed for two years.

Results: Among 594 patients, 220 (37 %) were aged >75 years. NTM-PD was confirmed in 192 cases, with 32 % occurring in elderly patients. The isolation rate was higher in older adults (13.8/100,000 vs. 2.94/100,000 in younger individuals), as was the disease rate (3.82/100,000 vs. 1.02/100,000). Older patients had fewer cavitated forms (27 vs 10 %), were less often diagnosed by bronchoscopy, and received proportionally less treatment despite meeting disease criteria. However, cure rates did not significantly differ between age groups.

Conclusions: Older adults exhibit a higher incidence of NTM isolation and disease but are managed with less aggressive diagnostic and therapeutic approaches, without compromising cure rates.

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老年人中的非结核性微生物。多中心研究。

背景：非结核分枝杆菌（NTM）肺病是一种日益常见的感染性疾病，尤其影响已有肺部疾病、免疫抑制和老年人。目的：确定老年人NTM隔离和NTM肺病（NTM- pd）的发病率，并描述其临床、放射学特征和治疗结果。方法：在西班牙北部五家三级医院进行回顾性（2012-2017）和前瞻性（2018-2020）的多中心观察性研究。所有年龄≥18岁且从呼吸道样本中分离出NTM的成年人纳入研究，随访2年。结果：594例患者中，220例（37%）年龄在50 ~ 75岁之间。NTM-PD确诊192例，其中32%为老年患者。老年人的分离率更高（13.8/10万比2.94/10万），发病率也更高（3.82/10万比1.02/10万）。老年患者空化形式较少（27% vs 10%），支气管镜检查诊断较少，尽管符合疾病标准，但接受的治疗比例较少。然而，治愈率在不同年龄组之间没有显著差异。结论：老年人表现出更高的NTM分离和疾病发生率，但采用较少积极的诊断和治疗方法进行管理，而不影响治愈率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory medicine 医学-呼吸系统

CiteScore

7.50

自引率

0.00%

发文量

199

审稿时长

38 days

期刊介绍： Respiratory Medicine is an internationally-renowned journal devoted to the rapid publication of clinically-relevant respiratory medicine research. It combines cutting-edge original research with state-of-the-art reviews dealing with all aspects of respiratory diseases and therapeutic interventions. Topics include adult and paediatric medicine, epidemiology, immunology and cell biology, physiology, occupational disorders, and the role of allergens and pollutants. Respiratory Medicine is increasingly the journal of choice for publication of phased trial work, commenting on effectiveness, dosage and methods of action.