Examining psychological protective mechanisms as moderators of the association between autistic traits and psychosis expression in a general population twin sample.

IF 3.5 2区医学 Q1 PSYCHIATRY

Schizophrenia Research Pub Date : 2025-10-01 Epub Date: 2025-08-06 DOI:10.1016/j.schres.2025.08.003

Melike Karaçam Doğan, Laura Fusar-Poli, Angelo Arias-Magnasco, Lotta-Katrin Pries, Bochao Danae Lin, Boris Klingenberg, Riccardo Bortoletto, Marco Colizzi, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Dina Collip, Philippe Delespaul, Marc De Hert, Catherine Derom, Evert Thiery, Nele Jacobs, Jim van Os, Bart Rutten, Jurjen Luykx, Thanavadee Prachason, Sinan Guloksuz

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引用次数: 0

Abstract

Background: Psychological protective factors, such as coping styles, extraversion, and optimal parenting, may reduce the risk of psychosis. However, their role in moderating the association between autistic traits (ATs) and psychosis expression (PE) remains understudied.

Methods: This study analyzed the first-wave data from the TwinssCan Project (n = 792 twins and siblings, 60.2 % female, mean age = 17.4 ± 3.6). ATs and PE were assessed using the Autism-Spectrum Quotient and the Community Assessment of Psychic Experiences (CAPE), respectively. Multilevel linear regression models were used to evaluate the moderating effects of seven coping styles (active coping, avoidance, reassuring thoughts, expressing emotions, seeking social support, palliative-reacting, and passive-reacting coping), extraversion, and optimal parenting.

Results: Seeking social support (B[95 %CI]:-0.005[-0.009,-0.001]), reassuring thoughts (B[95 %CI]:-0.005[-0.009,-0.001]), extraversion (B[95 %CI]: -0.03[-0.04,-0.01]) and optimal parenting (B[95 %CI]: -0.02[-0.03,0]) weakened the associations between ATs and CAPE total frequency scores, suggestive of protective mechanisms, whereas passive-reacting coping (B[95 %CI]:0.007[0.004,0.010]) strengthened this, suggestive of a risk factor. Additionally, avoidance(B[95 %CI]:0.09[0.02,0.16]) emerged as a risk factor in confirmatory analyses by significantly interacting with ATs in predicting CAPE total severity scores.

Conclusions: Engagement coping, extraversion, and optimal parenting may mitigate psychosis vulnerability in individuals with higher ATs, while passive-reactive coping and avoidance may heighten psychosis vulnerability. Although further research is needed, our findings provide a rationale for developing and testing targeted preventive strategies aimed at enhancing resilience in individuals with ATs.

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检查心理保护机制作为自闭症特征和精神病表达之间的关联调节在一般人群双胞胎样本。

背景：心理保护因素，如应对方式、外向性和最佳养育方式，可能会降低精神病的风险。然而，它们在调节自闭症特征（ATs）和精神病表达（PE）之间的关联中的作用仍未得到充分研究。方法：本研究分析twinscan项目的第一波资料（n = 792对双胞胎及兄弟姐妹，60.2%为女性，平均年龄= 17.4±3.6）。ATs和PE分别采用自闭症谱系商和社区心理体验评估（CAPE）进行评估。采用多水平线性回归模型评价了7种应对方式（主动应对、回避、安慰、情绪表达、寻求社会支持、缓和反应和被动反应应对）、外向性和最佳养育方式的调节作用。结果：寻求社会支持（B[95% CI]:-0.005[-0.009,-0.001]）、安心思想（B[95% CI]:-0.005[-0.009,-0.001]）、外向性（B[95% CI]: -0.03[-0.04,-0.01]）和最佳父母教养（B[95% CI]: -0.02[-0.03,0]）削弱了ATs和CAPE总频率得分之间的关联，提示保护机制，而被动反应应对（B[95% CI]:0.007[0.004,0.010]）加强了这一关联，提示风险因素。此外，在验证性分析中，回避（B[95% CI]:0.09[0.02,0.16]）在预测CAPE总严重程度评分时与ATs显著相互作用，成为风险因素。结论：参与应对、外向性和最佳养育方式可减轻高ATs个体的精神病易损性，而被动反应性应对和回避可加重高ATs个体的精神病易损性。虽然还需要进一步的研究，但我们的研究结果为开发和测试旨在提高ATs患者恢复力的有针对性的预防策略提供了依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Schizophrenia Research 医学-精神病学

CiteScore

7.50

自引率

8.90%

发文量

429

审稿时长

10.2 weeks

期刊介绍： As official journal of the Schizophrenia International Research Society (SIRS) Schizophrenia Research is THE journal of choice for international researchers and clinicians to share their work with the global schizophrenia research community. More than 6000 institutes have online or print (or both) access to this journal - the largest specialist journal in the field, with the largest readership! Schizophrenia Research''s time to first decision is as fast as 6 weeks and its publishing speed is as fast as 4 weeks until online publication (corrected proof/Article in Press) after acceptance and 14 weeks from acceptance until publication in a printed issue. The journal publishes novel papers that really contribute to understanding the biology and treatment of schizophrenic disorders; Schizophrenia Research brings together biological, clinical and psychological research in order to stimulate the synthesis of findings from all disciplines involved in improving patient outcomes in schizophrenia.