U-shaped association between daily eating frequency and nighttime fasting duration and depression in NHANES 2005-2018.

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2025-12-15 Epub Date: 2025-08-05 DOI:10.1016/j.jad.2025.120010

Yan Chen, Ruilan Gong, Qianzhu Li, Yina Wang, Lijun Wang, Xuanyang Wang

{"title":"U-shaped association between daily eating frequency and nighttime fasting duration and depression in NHANES 2005-2018.","authors":"Yan Chen, Ruilan Gong, Qianzhu Li, Yina Wang, Lijun Wang, Xuanyang Wang","doi":"10.1016/j.jad.2025.120010","DOIUrl":null,"url":null,"abstract":"Background: Existing studies display certain limitations and inconsistencies regarding the association between daily eating frequency (DEF) and nighttime fasting duration (NFD) and depression. We examines the relationships between DEF, NFD, and depression.Methods: Among the 29,035 subjects in the National Health and Nutrition Examination Survey (NHANES) 2005-2018, depression is defined by a total Patient Health Questionnaire-9 (PHQ-9) score of at least 10. DEF is quantified through the number of eating instances, and NFD is evaluated by examining the day's first and last meals. Weighted logistic regression models, restricted cubic spline (RCS), and mediation analysis are performed.Results: In comparison to DEF between 3.6 and 4.0 times, subjects with DEF ≤ 3 times (OR 1.28, 95 % CI 1.11-1.49) and DEF ≥ 4.6 times (OR 1.17, 95 % CI 1.01-1.34) have a greater risk of depression. Relative to NFD ranging from 12.1 to 13.3 h, those with NFD ≤ 10.8 h (OR 1.32, 95 % CI 1.14-1.52) and NFD ≥ 14.9 h (OR 1.37, 95 % CI 1.19-1.59) are at increased risk of depression. The U-shaped smoothing curves for the association further validate the findings. Blood urea nitrogen (BUN) and globulin (Glo) play a mediating role in the association. Among subjects having a lower daily energy intake, the impact of DEF and NFD on depression is more significant (Pinteraction < 0.05).Conclusions: DEF ≤ 3 or ≥ 4.6 times and NFD ≤ 10.8 or ≥ 14.9 h are independently related to increased depression risk.","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120010"},"PeriodicalIF":4.9000,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of affective disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jad.2025.120010","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/5 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Existing studies display certain limitations and inconsistencies regarding the association between daily eating frequency (DEF) and nighttime fasting duration (NFD) and depression. We examines the relationships between DEF, NFD, and depression.

Methods: Among the 29,035 subjects in the National Health and Nutrition Examination Survey (NHANES) 2005-2018, depression is defined by a total Patient Health Questionnaire-9 (PHQ-9) score of at least 10. DEF is quantified through the number of eating instances, and NFD is evaluated by examining the day's first and last meals. Weighted logistic regression models, restricted cubic spline (RCS), and mediation analysis are performed.

Results: In comparison to DEF between 3.6 and 4.0 times, subjects with DEF ≤ 3 times (OR 1.28, 95 % CI 1.11-1.49) and DEF ≥ 4.6 times (OR 1.17, 95 % CI 1.01-1.34) have a greater risk of depression. Relative to NFD ranging from 12.1 to 13.3 h, those with NFD ≤ 10.8 h (OR 1.32, 95 % CI 1.14-1.52) and NFD ≥ 14.9 h (OR 1.37, 95 % CI 1.19-1.59) are at increased risk of depression. The U-shaped smoothing curves for the association further validate the findings. Blood urea nitrogen (BUN) and globulin (Glo) play a mediating role in the association. Among subjects having a lower daily energy intake, the impact of DEF and NFD on depression is more significant (P_interaction < 0.05).

Conclusions: DEF ≤ 3 or ≥ 4.6 times and NFD ≤ 10.8 or ≥ 14.9 h are independently related to increased depression risk.

查看原文本刊更多论文

NHANES 2005-2018中每日进食频率和夜间禁食持续时间与抑郁症之间的u型关联。

背景：关于每日进食频率（DEF）和夜间禁食时间（NFD）与抑郁症之间的关系，现有研究显示出一定的局限性和不一致性。我们研究了DEF、NFD和抑郁症之间的关系。方法：在2005-2018年国家健康与营养检查调查（NHANES）的29,035名受试者中，抑郁症的定义是患者健康问卷-9 （PHQ-9）总分至少为10分。DEF是通过进食次数来量化的，NFD是通过检查一天的第一餐和最后一餐来评估的。进行了加权逻辑回归模型、限制三次样条（RCS）和中介分析。结果：与DEF在3.6 ~ 4.0倍之间相比，DEF ≤ 3倍（OR 1.28, 95 % CI 1.11 ~ 1.49）和DEF ≥ 4.6倍（OR 1.17, 95 % CI 1.01 ~ 1.34）的受试者抑郁风险更大。相对于NFD从12.1到13.3 h,那些NFD ≤10.8  h(或1.32,95 %可信区间1.14 - -1.52),NFD ≥14.9  h(或1.37,95 %可信区间1.19 - -1.59)增加抑郁的风险。该关联的u形平滑曲线进一步验证了研究结果。血尿素氮（BUN）和球蛋白（Glo）在这一关联中起中介作用。学科之间有一个较低的每日能量摄入,DEF和NFD抑郁的影响更重要(Pinteraction 结论:DEF ≤ 3或 ≥ 4.6倍,NFD ≤10.8 或 ≥14.9  h增加抑郁风险独立相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.