Dietary β-Carotene, Vitamin A, and Retinol Intake and Prevalence of Colorectal Adenoma: A Cross-Sectional Study and Meta-Analysis.

IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Gut and Liver Pub Date : 2025-08-08 DOI:10.5009/gnl250104
Joowon Chung, Jioh Kang, Sang Hoon Kim, Min Kyu Jung, Dong Hyun Kim, Hyun Joo Song, Ki Bae Kim, Seung-Joo Nam, Hoon Jai Chun, Jung Eun Lee, Yun Jeong Lim
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引用次数: 0

Abstract

Background/aims: Antioxidants may offer protection against colorectal cancer, but their association with colorectal adenomas remains unclear due to variations in study design, population, and dietary factors. We investigated the relationship between dietary intake of β-carotene, vitamin A, and retinol and the prevalence of colorectal adenoma using food frequency questionnaires (FFQs) and colonoscopy data.

Methods: We recruited participants undergoing elective colonoscopy across eight medical institutions. FFQs were administered prior to colonoscopy, and nutrient intakes were categorized into quartiles. Multivariate logistic regression was used to estimate odds ratios (ORs) adjusting for potential cofounders. A meta-analysis of 11 observational studies, including our own, was also conducted.

Results: Among 720 eligible participants (mean age 52.44±14.30 years; body mass index 23.82±3.46 kg/m2), colorectal adenoma was identified in 266 (36.9%). Higher intake of β-carotene and vitamin A was associated with a significantly lower prevalence of colorectal adenoma (p for trend <0.05). Adjusted ORs for the highest versus lowest quartile were 0.43 (95% confidence interval [CI], 0.20 to 0.91) for β-carotene and 0.34 (95% CI, 0.15 to 0.76) for vitamin A. Conversely, higher retinol intake was linked to increased adenoma prevalence (OR, 2.16; 95% CI, 1.09 to 4.29), particularly among individuals with high-fat diets. Meta-analysis confirmed a protective association for β-carotene (OR, 0.60; 95% CI, 0.46 to 0.78), but not for vitamin A or retinol.

Conclusions: We demonstrated an inverse association between β-carotene and colorectal adenoma prevalence, whereas the effects of vitamin A and retinol appeared to vary depending on dietary context. These findings highlight the complex influence of dietary pattern and nutrient sources on colorectal adenoma risk.

饮食中β-胡萝卜素、维生素A和视黄醇的摄入与结直肠腺瘤的发病率:一项横断面研究和荟萃分析
背景/目的:抗氧化剂可能具有预防结直肠癌的作用,但由于研究设计、人群和饮食因素的差异,抗氧化剂与结直肠腺瘤的关系尚不清楚。我们利用食物频率问卷(FFQs)和结肠镜检查数据调查了饮食中β-胡萝卜素、维生素A和视黄醇的摄入量与结直肠腺瘤患病率之间的关系。方法:我们在八家医疗机构招募了接受选择性结肠镜检查的参与者。在结肠镜检查之前给予ffq,并将营养摄入量分为四分位数。使用多变量逻辑回归来估计调整潜在联合创始人的比值比(ORs)。我们还对11项观察性研究(包括我们自己的研究)进行了荟萃分析。结果:720名符合条件的参与者(平均年龄52.44±14.30岁;体重指数(23.82±3.46 kg/m2),结直肠腺瘤266例(36.9%)。结论:我们证明β-胡萝卜素和维生素A的摄入与结直肠腺瘤患病率呈负相关,而维生素A和视黄醇的作用似乎因饮食环境而异。这些发现强调了饮食模式和营养来源对结直肠腺瘤风险的复杂影响。
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来源期刊
Gut and Liver
Gut and Liver 医学-胃肠肝病学
CiteScore
7.50
自引率
8.80%
发文量
119
审稿时长
6-12 weeks
期刊介绍: Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut and Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology. Gut and Liver is jointly owned and operated by 8 affiliated societies in the field of gastroenterology, namely: the Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, the Korean College of Helicobacter and Upper Gastrointestinal Research, the Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, the Korean Pancreatobiliary Association, and the Korean Society of Gastrointestinal Cancer.
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