Ontogenetic drivers of neutrophil heterogeneity

IF 2.1 4区医学 Q2 HEMATOLOGY

Experimental hematology Pub Date : 2025-08-06 DOI:10.1016/j.exphem.2025.104863

Ali Hageb , Merieme Farjia , Collins Osei-Sarpong , Carlos Silvestre-Roig

引用次数: 0

Abstract

Neutrophil development is a tightly regulated, multistep process involving stem cell commitment, differentiation, and maturation in the bone marrow. Chromatin remodeling, transcriptional networks, epigenetic reprogramming, metabolic adaptations, and structural changes collectively govern neutrophil production, shaping both maturation states and functional potential. Although these processes can be leveraged to adapt the neutrophil pool quantitatively and qualitatively during homeostasis or inflammatory stress, their dysregulation often drives disease progression. In this review, we examine how these ontogenetic factors specify neutrophil functions and underscore the significance of functional diversity across different maturation states.

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中性粒细胞异质性的个体发生驱动因素。

中性粒细胞的发育是一个严格调控的多步骤过程，涉及骨髓中干细胞的承诺、分化和成熟。染色质重塑、转录网络、表观遗传重编程、代谢适应和结构变化共同控制中性粒细胞的产生，塑造成熟状态和功能潜力。虽然这些过程可以在体内平衡或炎症应激期间定量和定性地适应中性粒细胞池，但它们的失调往往会导致疾病进展。在这篇综述中，我们研究了这些个体发生因素如何指定中性粒细胞功能，并强调了不同成熟状态下功能多样性的重要性。摘要：中性粒细胞通过动态的表观遗传、转录、结构和代谢变化进化，微调其成熟度和功能。这些过程在健康和疾病中校准中性粒细胞池，但失调可以驱动病理。这篇综述探讨了发育线索如何塑造中性粒细胞生物学，并强调了不同成熟状态下功能多样性的关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental hematology 医学-血液学

CiteScore

5.30

自引率

0.00%

发文量

审稿时长

58 days

期刊介绍： Experimental Hematology publishes new findings, methodologies, reviews and perspectives in all areas of hematology and immune cell formation on a monthly basis that may include Special Issues on particular topics of current interest. The overall goal is to report new insights into how normal blood cells are produced, how their production is normally regulated, mechanisms that contribute to hematological diseases and new approaches to their treatment. Specific topics may include relevant developmental and aging processes, stem cell biology, analyses of intrinsic and extrinsic regulatory mechanisms, in vitro behavior of primary cells, clonal tracking, molecular and omics analyses, metabolism, epigenetics, bioengineering approaches, studies in model organisms, novel clinical observations, transplantation biology and new therapeutic avenues.