Are There Non-Mammalian Models of Mismatch Negativity? A Translational Tribute to Risto Näätänen.

IF 2.4 4区 医学 Q3 NEUROSCIENCES
Sofia S Chahlova, Adam Michael Stewart, David S Galstyan, Murilo S de Abreu, Allan V Kalueff
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引用次数: 0

Abstract

Mismatch negativity (MMN), first described by Risto Näätänen in the late 1970s, is now known as a key phenomenon in the brain, reflecting its ability to detect differences in the presented sensory stimuli. Although MMN has been widely studied in both humans and other mammals, the phenomenon has also been increasingly examined in non-mammalian species in recent years. Here, we discuss the role of MMN as an evolutionarily conserved phenotype across taxa, and its general translational significance in neuroscience. Despite challenges of studying MMN in non-mammalian species (especially due to methodological limitations and differences in sensory processing), these model organisms offer important insights into brain sensory and cognitive processing that can have further clinical implications in diagnosing and treating brain disorders. This paper is a scientific tribute to Professor R. Näätänen (1939-2023), a brilliant neuroscientist, colleague, and friend.

是否存在非哺乳动物的错配消极模式?翻译致敬Risto Näätänen。
错配负性(MMN),最早由Risto Näätänen在20世纪70年代末描述,现在被认为是大脑中的一个关键现象,反映了它在呈现的感官刺激中检测差异的能力。虽然MMN已经在人类和其他哺乳动物中得到了广泛的研究,但近年来,这种现象在非哺乳动物物种中也得到了越来越多的研究。在这里,我们讨论了MMN作为一种进化上保守的表型在整个分类群中的作用,以及它在神经科学中的一般翻译意义。尽管在非哺乳动物物种中研究MMN存在挑战(特别是由于方法的限制和感觉处理的差异),但这些模式生物为大脑感觉和认知处理提供了重要的见解,可以在诊断和治疗脑部疾病方面具有进一步的临床意义。这篇论文是对R. Näätänen教授(1939-2023)的科学致敬,他是一位杰出的神经科学家、同事和朋友。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
European Journal of Neuroscience
European Journal of Neuroscience 医学-神经科学
CiteScore
7.10
自引率
5.90%
发文量
305
审稿时长
3.5 months
期刊介绍: EJN is the journal of FENS and supports the international neuroscientific community by publishing original high quality research articles and reviews in all fields of neuroscience. In addition, to engage with issues that are of interest to the science community, we also publish Editorials, Meetings Reports and Neuro-Opinions on topics that are of current interest in the fields of neuroscience research and training in science. We have recently established a series of ‘Profiles of Women in Neuroscience’. Our goal is to provide a vehicle for publications that further the understanding of the structure and function of the nervous system in both health and disease and to provide a vehicle to engage the neuroscience community. As the official journal of FENS, profits from the journal are re-invested in the neuroscientific community through the activities of FENS.
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