Elmira Karimi, Michelle A Keske, Mohammad Beba, Gunveen Kaur
{"title":"Effects of omega-3 fatty acids on skeletal muscle vascular health and metabolism.","authors":"Elmira Karimi, Michelle A Keske, Mohammad Beba, Gunveen Kaur","doi":"10.1097/MCO.0000000000001155","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>This review aims to summarise recent findings on the effects of omega-3 fatty acids (FAs) on skeletal muscle vascular and metabolic health. We particularly focus on macrovascular (large blood vessel) outcomes, skeletal muscle microvascular (capillary) blood flow and skeletal muscle health and metabolism.</p><p><strong>Recent findings: </strong>Recent meta-analysis and intervention studies suggest that omega-3 FAs improve macrovascular health outcomes in humans by enhancing endothelial function, reducing arterial stiffness and by increasing nitric oxide bioavailability. However, the benefits on macrovascular outcomes are more evident in clinical populations than in healthy individuals. In terms of dose, more than 1 g/day of omega-3 FA appear to be more beneficial than less than 1 g/day. In contrast to macrovascular outcomes, the effect of omega-3 FAs on skeletal muscle microvascular outcomes remains undetermined, demonstrating a significant gap in the field. In terms of skeletal muscle health and metabolism, omega-3 FAs improve muscle strength and ameliorate postprandial blood glucose levels in healthy individuals. The anti-inflammatory effects of omega-3 FAs also appear to benefit muscle health and metabolism.</p><p><strong>Summary: </strong>Omega-3 FAs have a positive effect on macrovascular outcomes, muscle metabolism and health, specifically in clinical populations. The direct effects of omega-3 FAs on muscle microvascular outcomes in both healthy and clinical populations need to be determined.</p>","PeriodicalId":10962,"journal":{"name":"Current Opinion in Clinical Nutrition and Metabolic Care","volume":" ","pages":"496-500"},"PeriodicalIF":3.5000,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Clinical Nutrition and Metabolic Care","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MCO.0000000000001155","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/1 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose of review: This review aims to summarise recent findings on the effects of omega-3 fatty acids (FAs) on skeletal muscle vascular and metabolic health. We particularly focus on macrovascular (large blood vessel) outcomes, skeletal muscle microvascular (capillary) blood flow and skeletal muscle health and metabolism.
Recent findings: Recent meta-analysis and intervention studies suggest that omega-3 FAs improve macrovascular health outcomes in humans by enhancing endothelial function, reducing arterial stiffness and by increasing nitric oxide bioavailability. However, the benefits on macrovascular outcomes are more evident in clinical populations than in healthy individuals. In terms of dose, more than 1 g/day of omega-3 FA appear to be more beneficial than less than 1 g/day. In contrast to macrovascular outcomes, the effect of omega-3 FAs on skeletal muscle microvascular outcomes remains undetermined, demonstrating a significant gap in the field. In terms of skeletal muscle health and metabolism, omega-3 FAs improve muscle strength and ameliorate postprandial blood glucose levels in healthy individuals. The anti-inflammatory effects of omega-3 FAs also appear to benefit muscle health and metabolism.
Summary: Omega-3 FAs have a positive effect on macrovascular outcomes, muscle metabolism and health, specifically in clinical populations. The direct effects of omega-3 FAs on muscle microvascular outcomes in both healthy and clinical populations need to be determined.
期刊介绍:
A high impact review journal which boasts an international readership, Current Opinion in Clinical Nutrition and Metabolic Care offers a broad-based perspective on the most recent and exciting developments within the field of clinical nutrition and metabolic care. Published bimonthly, each issue features insightful editorials and high quality invited reviews covering two or three key disciplines which include protein, amino acid metabolism and therapy, lipid metabolism and therapy, nutrition and the intensive care unit and carbohydrates. Each discipline introduces world renowned guest editors to ensure the journal is at the forefront of knowledge development and delivers balanced, expert assessments of advances from the previous year.