Epidemiology of Pruritus: Global Burden of Disease Research from 1990 to 2021 and Future Trend Predictions.

IF 2.7 3区医学 Q2 DERMATOLOGY

Dermatology Pub Date : 2025-08-07 DOI:10.1159/000547821

Zirui Wang, Shuai Han, Xiaoshan Huang, Benmeng Wu, Chunyan Mei, Hui Liu, Min Wu

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引用次数: 0

Abstract

Introduction: Pruritus, the most common dermatological symptom, lacks comprehensive global epidemiological data. This study analyzed pruritus trends from 1990 to 2021 using the Global Burden of Disease (GBD) 2021 dataset to inform prevention strategies.

Methods: Data on pruritus incidence, prevalence, and disability-adjusted life years were extracted. Temporal trends were assessed using joinpoint regression, while age-period-cohort modeling evaluated age, period, and cohort effects. Socio-demographic index (SDI) correlations and future trends were analyzed using spline models and autoregressive integrated moving average projections.

Results: In 2021, 80.65 million individuals (95% uncertainty interval: 72.30-89.30 million) were affected by pruritus, with 62.53 million new cases (95% confidence interval [CI]: 55.87-70.33 million), doubling since 1990. The age-standardized prevalence rate (ASPR) and age-standardized incidence rate (ASIR) showed annual increases of 0.3352% (95% CI: 0.3247-0.3456) and 0.3168% (95% CI: 0.3063-0.3272), respectively. Higher SDI regions had lower pruritus burdens. The highest risk occurred in the 80-84 age group, with incidence and cohort effects steadily rising. By 2050, ASIR, ASPR, and ASDR are projected to reach 939.33, 1194.41, and 12.52 for females, and 716.82, 933.25, and 9.90 for males.

Conclusion: Pruritus burden has steadily increased over 3 decades, with the elderly most affected. As the global population ages, targeted strategies are essential to mitigate its growing impact.

查看原文本刊更多论文

瘙痒的流行病学——1990年至2021年全球疾病负担研究和未来趋势预测。

背景：瘙痒症是最常见的皮肤病症状，缺乏全面的全球流行病学资料。本研究利用全球疾病负担（GBD） 2021数据集分析了1990年至2021年的瘙痒趋势，为预防策略提供信息。方法：提取瘙痒症发病率、患病率和残疾调整生命年（DALYs）的数据。使用连接点回归评估时间趋势，而年龄-时期-队列模型评估年龄、时期和队列效应。利用样条模型和自回归综合移动平均预测分析了社会人口指数（SDI）的相关性和未来趋势。结果：2021年，共有8065万人（95%不确定区间（UI）： 7230万~ 8930万）出现瘙痒，新发病例6253万（95%可信区间（CI）： 5587万~ 7033万），较1990年翻了一番。年龄标准化患病率（ASPR）和发病率（ASIR）的年增长率分别为0.3352% （95% CI: 0.3247 ~ 0.3456）和0.3168% （95% CI: 0.3063 ~ 0.3272）。高SDI地区瘙痒负担较低。最高风险发生在80-84岁年龄组，发病率和队列效应稳步上升。到2050年，预计女性ASIR、ASPR和ASDR分别为939.33、1194.41和12.52，男性为716.82、933.25和9.90。结论：30多年来，瘙痒症负担稳步增加，以老年人为主。随着全球人口老龄化，有针对性的战略对于减轻其日益严重的影响至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatology 医学-皮肤病学

CiteScore

6.40

自引率

2.90%

发文量

审稿时长

1 months

期刊介绍： Published since 1893, ''Dermatology'' provides a worldwide survey of clinical and investigative dermatology. Original papers report clinical and laboratory findings. In order to inform readers of the implications of recent research, editorials and reviews prepared by invited, internationally recognized scientists are regularly featured. In addition to original papers, the journal publishes rapid communications, short communications, and letters to ''Dermatology''. ''Dermatology'' answers the complete information needs of practitioners concerned with progress in research related to skin, clinical dermatology and therapy. The journal enjoys a high scientific reputation with a continually increasing impact factor and an equally high circulation.