Visuospatial impairment and resting-state network correlations in Alzheimer's disease: A systematic review.

IF 2.3 3区 心理学 Q2 BEHAVIORAL SCIENCES
Behavioural Brain Research Pub Date : 2025-10-18 Epub Date: 2025-08-05 DOI:10.1016/j.bbr.2025.115770
Ho Yan Lai, Andi Tri Supratno Musrah, Kah Hui Yap, Yong En Chow, Naaz Salim, Noor Shatirah Voon
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引用次数: 0

Abstract

Background: Alzheimer's disease (AD) exhibits distinct visuospatial impairments across its clinical subtypes, including typical amnestic AD and posterior cortical atrophy (PCA). Resting-state functional MRI (rs-fMRI) reveals disruptions in large-scale brain networks, yet the relationship between connectivity alterations and visuospatial deficits remains unclear.

Objective: We investigated visuospatial deficits across AD subtypes and identified affected brain networks to inform clinical interventions.

Methods: Six studies were reviewed by comparing visuospatial performance and rs-fMRI-derived functional connectivity in AD and healthy controls (HC). Effect sizes (Bonett's δ) for behavioral tasks and correlation coefficients (r) for imaging-clinical associations were synthesized.

Results: Patients with AD exhibited significant visuospatial deficits, with moderate to large effect sizes in amnestic AD (δ = 1.0-1.5) and severe impairments in PCA (δ ≥ 3.0). Rs-fMRI revealed disrupted connectivity in three key networks: dorsal parietal-occipital networks (strongly linked to visuospatial deficits, especially in PCA), default mode network (DMN) (associated with memory but indirectly contributing to visual integration), and cerebellar-cortical circuits (implicated in early AD). Moderate correlations (r = 0.33-0.44, p < 0.05) were found between connectivity loss (DMN, cerebellar) and poor Rey-Osterrieth Complex Figure (ROCF) performance. However, some studies reported null associations, possibly due to compensatory mechanisms or methodological heterogeneity.

Conclusion: AD subtypes exhibit distinct network dysfunction patterns, with PCA showing severe posterior network disruption and amnestic AD involving broader DMN and cerebellar degeneration. Rs-fMRI provides valuable insights into the neural basis of visuospatial deficits, suggesting potential biomarkers for subtype-specific diagnosis and intervention.

阿尔茨海默病的视觉空间损害和静息状态网络相关性:一项系统综述。
背景:阿尔茨海默病(AD)在其临床亚型中表现出明显的视觉空间障碍,包括典型的遗忘性AD和后皮质萎缩(PCA)。静息状态功能MRI (rs-fMRI)揭示了大规模大脑网络的中断,但连接改变与视觉空间缺陷之间的关系尚不清楚。目的:我们研究了AD亚型的视觉空间缺陷,并确定了受影响的大脑网络,为临床干预提供信息。方法:回顾了6项研究,比较了AD和健康对照(HC)的视觉空间表现和rs- fmri衍生的功能连通性。综合行为任务的效应量(Bonett’s δ)和影像-临床关联的相关系数(r)。结果:AD患者表现出明显的视觉空间缺陷,其中遗忘性AD表现为中等到较大的效应量(δ = 1.0-1.5), PCA表现为严重的损伤(δ≥3.0)。Rs-fMRI显示三个关键网络的连通性被破坏:背侧顶叶-枕叶网络(与视觉空间缺陷密切相关,特别是在PCA中),默认模式网络(DMN)(与记忆相关,但间接促进视觉整合)和小脑-皮质回路(与早期AD有关)。连通性丧失(DMN、小脑)与不良的Rey-Osterrieth Complex Figure (ROCF)表现之间存在中度相关性(r = 0.33-0.44, p < 0.05)。然而,一些研究报告无关联,可能是由于代偿机制或方法异质性。结论:AD亚型表现出不同的网络功能障碍模式,PCA表现出严重的后网络破坏,健忘性AD涉及更广泛的DMN和小脑变性。Rs-fMRI为视觉空间缺陷的神经基础提供了有价值的见解,为亚型特异性诊断和干预提供了潜在的生物标志物。
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来源期刊
Behavioural Brain Research
Behavioural Brain Research 医学-行为科学
CiteScore
5.60
自引率
0.00%
发文量
383
审稿时长
61 days
期刊介绍: Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.
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