Chagas and Vector-Borne Disease Exposures in an Indigenous Community in the Ecuadorian Amazon: A Retrospective Study.

IF 1.6 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

American Journal of Tropical Medicine and Hygiene Pub Date : 2025-08-07 Print Date: 2025-10-01 DOI:10.4269/ajtmh.25-0200

Rojelio Mejia, Bin Zhan, Nestor L Uzcategui, Andrea Lopez, Philip Cooper, Natalia Romero-Sandoval

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引用次数: 0

Abstract

There are limited data on vector-borne diseases from the Ecuadorian Amazon, particularly among marginalized Indigenous populations. From a survey of Shuar communities in Ecuador, we measured IgG antibodies to Trypanosoma cruzi, dengue virus, and Leishmania spp. The prevalence of IgG antibodies was 7.4% for T. cruzi, 21.3% for dengue, and 96.8% for Leishmania spp. There was an increase in the risk of dengue infections with increasing age (per year; adjusted odds ratio [adj. OR]: 1.03, 95% CI: 1.01-1.05, P = 0.001) and among females (adj. OR: 2.17, 95% CI: 1.03-4.57, P = 0.041). There was an increase in T. cruzi anti-Tc24 IgG antibody levels with greater age (Spearman r = 0.553, P = 0.05). This study showed a high prevalence or exposure to Chagas disease, dengue, and Leishmania spp. There remains an unmet need for surveillance to monitor the transmission of Chagas and other vector-borne diseases and their associated morbidity in marginalized communities in the Ecuadorian Amazon.

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厄瓜多尔亚马逊地区土著社区恰加斯病和媒介传播疾病暴露：一项回顾性研究。

关于厄瓜多尔亚马逊地区病媒传播疾病的数据有限，特别是在边缘化土著人口中。通过对厄瓜多尔Shuar社区的调查，我们检测了克氏锥虫、登革热病毒和利什曼原虫的IgG抗体，克氏锥虫、登革热病毒和利什曼原虫的IgG抗体阳性率分别为7.4%、21.3%和96.8%，随着年龄的增长，登革热感染的风险增加(每年；校正优势比[j. OR]: 1.03, 95% CI: 1.01-1.05, P = 0.001)，女性（j. OR: 2.17, 95% CI: 1.03-4.57, P = 0.041）。克氏锥虫抗tc24 IgG抗体水平随年龄增大而升高（Spearman r = 0.553, P = 0.05）。该研究显示，南美锥虫病、登革热和利什曼原虫的高流行率或暴露率，在厄瓜多尔亚马逊地区边缘社区监测南美锥虫病和其他媒介传播疾病的传播及其相关发病率的监测需求仍未得到满足。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Tropical Medicine and Hygiene 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.20

自引率

3.00%

发文量

508

审稿时长

3 months

期刊介绍： The American Journal of Tropical Medicine and Hygiene, established in 1921, is published monthly by the American Society of Tropical Medicine and Hygiene. It is among the top-ranked tropical medicine journals in the world publishing original scientific articles and the latest science covering new research with an emphasis on population, clinical and laboratory science and the application of technology in the fields of tropical medicine, parasitology, immunology, infectious diseases, epidemiology, basic and molecular biology, virology and international medicine. The Journal publishes unsolicited peer-reviewed manuscripts, review articles, short reports, images in Clinical Tropical Medicine, case studies, reports on the efficacy of new drugs and methods of treatment, prevention and control methodologies,new testing methods and equipment, book reports and Letters to the Editor. Topics range from applied epidemiology in such relevant areas as AIDS to the molecular biology of vaccine development. The Journal is of interest to epidemiologists, parasitologists, virologists, clinicians, entomologists and public health officials who are concerned with health issues of the tropics, developing nations and emerging infectious diseases. Major granting institutions including philanthropic and governmental institutions active in the public health field, and medical and scientific libraries throughout the world purchase the Journal. Two or more supplements to the Journal on topics of special interest are published annually. These supplements represent comprehensive and multidisciplinary discussions of issues of concern to tropical disease specialists and health issues of developing countries