Deep brain stimulation for neurological and neurodevelopmental disorders in children: Current applications and future perspectives.

IF 4.3 2区医学 Q1 CLINICAL NEUROLOGY

Developmental Medicine and Child Neurology Pub Date : 2025-08-06 DOI:10.1111/dmcn.16452

Sydney A McQueen, Carolina Gorodetsky, George M Ibrahim

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Abstract

Deep brain stimulation (DBS) has advanced the treatment of refractory neurological and neuropsychiatric conditions in adults, offering a reversible and adjustable therapy. While its application among children remains in its infancy, DBS holds potential for the treatment of conditions such as dystonia, epilepsy, and neurodevelopmental disorders including severe self-injurious behaviour. Paediatric DBS introduces unique opportunities for early intervention during critical periods of neuroplasticity, but also presents challenges related to developmental impacts, ethical considerations, and a limited evidence base. This review outlines the current state of DBS in children, highlighting key indications, clinical outcomes, and barriers to more widespread implementation. Advances in biomarkers and adaptive stimulation technologies are poised to refine patient selection and treatment paradigms, while multisite collaborations will be essential in building robust evidence and improving accessibility. As DBS evolves, it offers hope for improving the quality of life of children and their families facing a number of severe, treatment-resistant conditions.

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脑深部电刺激治疗儿童神经和神经发育障碍：当前应用和未来展望。

深部脑刺激（DBS）提供了一种可逆和可调节的治疗方法，促进了成人难治性神经和神经精神疾病的治疗。虽然DBS在儿童中的应用仍处于起步阶段，但它在治疗肌张力障碍、癫痫和包括严重自残行为在内的神经发育障碍等疾病方面具有潜力。在神经可塑性的关键时期，儿科DBS为早期干预提供了独特的机会，但也提出了与发育影响、伦理考虑和有限的证据基础相关的挑战。这篇综述概述了DBS在儿童中的现状，强调了关键适应症、临床结果和更广泛实施的障碍。生物标志物和适应性刺激技术的进步将有助于改进患者选择和治疗范例，而多站点合作对于建立可靠的证据和改善可及性至关重要。随着脑起搏术的发展，它为改善儿童及其家庭的生活质量带来了希望，这些儿童面临着许多严重的、难以治疗的疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental Medicine and Child Neurology 医学-临床神经学

CiteScore

7.80

自引率

13.20%

发文量

338

审稿时长

3-6 weeks

期刊介绍： Wiley-Blackwell is pleased to publish Developmental Medicine & Child Neurology (DMCN), a Mac Keith Press publication and official journal of the American Academy for Cerebral Palsy and Developmental Medicine (AACPDM) and the British Paediatric Neurology Association (BPNA). For over 50 years, DMCN has defined the field of paediatric neurology and neurodisability and is one of the world’s leading journals in the whole field of paediatrics. DMCN disseminates a range of information worldwide to improve the lives of disabled children and their families. The high quality of published articles is maintained by expert review, including independent statistical assessment, before acceptance.