Prefrontal Cortex Recruitment to Food Stimuli Differs in Overweight/Obesity and Binge Eating Disorder.

IF 3.4 2区心理学 Q1 PSYCHIATRY

European Eating Disorders Review Pub Date : 2025-08-06 DOI:10.1002/erv.70020

Jennifer Svaldi, Betti Schopp, Philipp A Schroeder, Dustin Werle, Ann-Christine Ehlis

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引用次数: 0

Abstract

Background: At a phenotypical level, the repeated occurrence of binge eating episodes clearly differentiates individuals with binge eating disorder (BED) from individuals with overweight but without BED. Their neural profiles during food-related inhibition, however, indicate prefrontal hypoactivation in both groups. The present study investigated differential neural activations in upper lateral (right dorsolateral prefrontal cortex [DLPFC]) and inferior (right inferior frontal gyrus [IFG]) control regions during food-related inhibition by functional near-infrared spectroscopy (fNIRS). In addition, activity in reward-related brain regions (orbitofrontal cortex [OFC]) during stimulus processing was measured.

Method: Individuals with BED (n = 32), a control group of individuals with overweight and without BED (OWC, n = 21), and a control group of individuals with normal weight and without BED (NWC; n = 31) underwent a Go/No-Go (GNG) and a stimulus degradation task during fNIRS, both with food and non-food stimuli in counterbalanced order.

Results: Most predicted outcomes were not significant. Neural recordings during GNG underscore prefrontal hypoactivation in both BED and OWC relative to NWC, however, with differential alterations: In the Food-NoGo condition, the BED group displayed hypoactivation in the IFG, while the OWC showed hypoactivation in the DLPFC.

Conclusions: The results suggest differential requirements for DLPFC and IFG recruitment during food-related inhibition in individuals with BED and overweight.

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前额叶皮层对食物刺激的招募在超重/肥胖和暴食症中是不同的。

背景：在表型水平上，暴食发作的反复发生清楚地区分了暴食症（BED）患者与超重但无BED的个体。然而，在食物相关的抑制过程中，他们的神经图谱表明，两组人的前额叶活性降低。本研究利用功能性近红外光谱（fNIRS）研究了食物相关抑制过程中上侧（右背外侧前额叶皮层[DLPFC]）和下侧（右额下回[IFG]）控制区的不同神经激活。此外，还测量了刺激处理过程中与奖励相关的大脑区域（眶额皮质[OFC]）的活动。方法：有BED的个体（n = 32），超重但没有BED的个体（OWC, n = 21）作为对照组，体重正常但没有BED的个体(NWC；n = 31)在fNIRS期间进行了Go/No-Go （GNG）和刺激降解任务，食物和非食物刺激均以平衡顺序进行。结果：大多数预测结果不显著。GNG期间的神经记录显示，与NWC相比，BED组和OWC组的前额叶活动减弱，但变化有所不同：在Food-NoGo的情况下，BED组的IFG活动减弱，而OWC组的DLPFC活动减弱。结论：研究结果表明，BED和超重个体在食物相关抑制过程中对DLPFC和IFG募集的需求存在差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Eating Disorders Review PSYCHOLOGY, CLINICAL-

CiteScore

8.90

自引率

7.50%

发文量

期刊介绍： European Eating Disorders Review publishes authoritative and accessible articles, from all over the world, which review or report original research that has implications for the treatment and care of people with eating disorders, and articles which report innovations and experience in the clinical management of eating disorders. The journal focuses on implications for best practice in diagnosis and treatment. The journal also provides a forum for discussion of the causes and prevention of eating disorders, and related health policy. The aims of the journal are to offer a channel of communication between researchers, practitioners, administrators and policymakers who need to report and understand developments in the field of eating disorders.