Pedalling towards better health: a randomised controlled trial of aerobic cycling to improve glycaemic control and quality of life in middle-aged men with type 2 diabetes.
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Abstract
Objective: To evaluate the 3-month impact of aerobic cycling on metabolic health and quality of life in middle-aged men with type 2 diabetes in a randomised controlled trial.
Method: A randomised controlled trial was conducted from July to November 2023 in five government hospitals in Lahore, Pakistan. A total of 120 male patients with type 2 diabetes mellitus (aged 50-65 years, body mass index (BMI) >25 kg/m², fasting plasma glucose (FPG) >140 mg/dL) were randomised into an exercise group (EG, n=60) and a control group (CG, n=60). The EG underwent a supervised aerobic cycling programme for 12 weeks (4 sessions/week, 50 min/session), while the CG continued usual care. Outcomes including BMI, weight, waist-to-hip ratio (WHR), FPG, blood pressure (BP), fat mass and Diabetes Quality of Life (DQOL) were measured preintervention and postintervention. Data were analysed using independent t-tests and multivariate regression (p<0.05).
Results: 115 participants completed the study (eg,=55, CG=60). Postintervention, the EG showed significant reductions in FPG (154.6±22.6 vs 174.8±20.2 mg/dL; p=0.004), systolic BP (129.9±13.8 vs 145.2±16.8 mm Hg; p=0.003), diastolic BP (79.2±8.1 vs 82.0±8.8 mm Hg; p=0.022), fat mass (38.2%±7.1% vs 42.0%±6.2%; p=0.005) and WHR (1.0±0.1 vs 0.9±0.1; p=0.045). DQOL scores improved significantly in the EG (2.5±0.53) vs CG (3.5±1.2; p=0.004). Weight and BMI also decreased in the EG (p=0.047, p=0.053). Multivariate regression showed exercise as a significant predictor of weight loss (β=-1.5, p=0.004).
Conclusions: A 3-month aerobic cycling programme significantly enhanced metabolic health and quality of life in middle-aged men with type 2 diabetes.
目的：通过一项随机对照试验，评估3个月有氧循环对中年男性2型糖尿病患者代谢健康和生活质量的影响。方法：于2023年7月至11月在巴基斯坦拉合尔5家政府医院进行随机对照试验。将120例男性2型糖尿病患者(年龄50 ~ 65岁，体重指数（BMI) >25 kg/m²，空腹血糖(FPG) >140 mg/dL）随机分为运动组（EG, n=60）和对照组（CG, n=60）。EG组进行了为期12周的有氧自行车训练（4次/周，50分钟/次），而CG组继续进行常规护理。测量干预前和干预后的BMI、体重、腰臀比（WHR）、FPG、血压（BP）、脂肪量和糖尿病生活质量（DQOL）。使用独立t检验和多变量回归分析数据(结果：115名参与者完成了研究（例如，=55，CG=60）。干预后，EG显示FPG显著降低(154.6±22.6 vs 174.8±20.2 mg/dL；p=0.004)，收缩压(129.9±13.8 vs 145.2±16.8 mm Hg；p=0.003)，舒张压(79.2±8.1 vs 82.0±8.8 mm Hg；P =0.022)，脂肪量(38.2%±7.1% vs 42.0%±6.2%；p=0.005)和WHR(1.0±0.1 vs 0.9±0.1；p = 0.045)。EG组DQOL评分（2.5±0.53）显著高于CG组（3.5±1.2）；p = 0.004)。EG组的体重和BMI也有所下降（p=0.047, p=0.053）。多变量回归显示运动是体重减轻的显著预测因子（β=-1.5, p=0.004）。结论：3个月有氧自行车运动可显著改善2型糖尿病中年男性患者的代谢健康和生活质量。
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