CGRP-mediated neural addiction in tumor dynamic remodeling.

IF 17.5 1区医学 Q1 ONCOLOGY

Trends in cancer Pub Date : 2025-09-01 Epub Date: 2025-08-05 DOI:10.1016/j.trecan.2025.07.004

Miaochun Xu, Yang Yu, Canhui Cao

引用次数: 0

Abstract

Neuro-tumor crosstalk is reshaping our understanding of cancer. Increasing data demonstrate that calcitonin gene-related peptide (CGRP) is a key neural driver of tumor growth, immune suppression, and cancer-associated symptoms, positioning CGRP-mediated neural addiction as a promising therapeutic target to disrupt tumor-nerve interactions and improve outcomes in patients with cancer.

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cgrp介导的神经成瘾在肿瘤动态重塑中的作用。

神经肿瘤的相声正在重塑我们对癌症的认识。越来越多的数据表明，降钙素基因相关肽（CGRP）是肿瘤生长、免疫抑制和癌症相关症状的关键神经驱动因素，将CGRP介导的神经成瘾定位为破坏肿瘤-神经相互作用和改善癌症患者预后的有希望的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in cancer Medicine-Oncology

CiteScore

28.50

自引率

0.50%

发文量

138

期刊介绍： Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.