Di He, Zeqi Hao, Mengqi Zhao, Mengting Li, Na Hou, Yang Yu, Lulu Cheng, Xize Jia
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引用次数: 0
Abstract
Background: Type 2 diabetes mellitus (T2DM) is a prevalent chronic condition associated with a range of abnormalities in both the functional and structural aspects of the brain. However, existing studies have produced inconsistent results due to disease heterogeneity and small sample size. Therefore, we aim to examine common functional and structural alterations in patients with T2DM.
Method: We searched PubMed, Web of Science, and Embase (published before July 2023) and included a total of 52 valid studies (58 datasets), which have 2160 patients with T2DM and 2124 healthy controls (HCs). Then, we used the anisotropic effect size seed-based d mapping (AES-SDM) to examine changes in neural activity and grey matter volume (GMV) in patients with T2DM. To validate the findings of the AES-SDM results, two additional meta-analyses were performed using activation likelihood estimation (ALE) and multilevel kernel density analysis (MKDA).
Results: The results showed that patients with T2DM exhibited abnormal neural activity, functional connectivity of default mode network, and GMV in brain regions related to visual processing, such as the occipital lobe, lingual gyrus, and Heschl's gyrus. In addition, functional or structural alterations were also found in other sensory-motor, cognitive, and attention-related brain regions in patients with T2DM. The results of ALE and MKDA fundamentally confirmed the findings of the AES-SDM analysis.
Conclusion: These findings offer robust neural markers and deepen our understanding of the neurobiological underpinnings of T2DM.
背景：2型糖尿病（T2DM）是一种常见的慢性疾病，与大脑功能和结构方面的一系列异常有关。然而，由于疾病异质性和样本量小，现有的研究结果不一致。因此，我们的目的是研究T2DM患者常见的功能和结构改变。方法：检索PubMed、Web of Science和Embase（在2023年7月前发表），共纳入52项有效研究（58个数据集），其中2160例T2DM患者和2124例健康对照（hc）。然后，我们使用各向异性效应大小基于种子的d映射（AES-SDM）来检测T2DM患者神经活动和灰质体积（GMV）的变化。为了验证AES-SDM结果的发现，使用激活似然估计（ALE）和多级核密度分析（MKDA）进行了两个额外的荟萃分析。结果：T2DM患者在枕叶、舌回、Heschl’s回等与视觉加工相关的脑区出现神经活动异常、默认模式网络功能连通性异常、GMV异常。此外，T2DM患者的其他感觉-运动、认知和注意力相关脑区也存在功能或结构改变。ALE和MKDA的结果从根本上证实了AES-SDM分析的结果。结论：这些发现提供了强有力的神经标志物，加深了我们对2型糖尿病神经生物学基础的理解。
期刊介绍：
Psychiatry has suffered tremendously by the limited translational pipeline. Nobel laureate Julius Axelrod''s discovery in 1961 of monoamine reuptake by pre-synaptic neurons still forms the basis of contemporary antidepressant treatment. There is a grievous gap between the explosion of knowledge in neuroscience and conceptually novel treatments for our patients. Translational Psychiatry bridges this gap by fostering and highlighting the pathway from discovery to clinical applications, healthcare and global health. We view translation broadly as the full spectrum of work that marks the pathway from discovery to global health, inclusive. The steps of translation that are within the scope of Translational Psychiatry include (i) fundamental discovery, (ii) bench to bedside, (iii) bedside to clinical applications (clinical trials), (iv) translation to policy and health care guidelines, (v) assessment of health policy and usage, and (vi) global health. All areas of medical research, including — but not restricted to — molecular biology, genetics, pharmacology, imaging and epidemiology are welcome as they contribute to enhance the field of translational psychiatry.
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