Exploring regional variations in probiotics: Implications for efficacy and application.

IF 3.5 3区 医学 Q3 IMMUNOLOGY
Microbial pathogenesis Pub Date : 2025-11-01 Epub Date: 2025-08-07 DOI:10.1016/j.micpath.2025.107963
Mohammad Abavisani, Niloofar Khoshroo, Pourya Tafti, Mohammad Akbari Moghadam, Prashant Kesharwani, Amirhossein Sahebkar
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引用次数: 0

Abstract

Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. These bacteria can affect health conditions by virtue of influencing immune system components, modulating of host signaling, and modifying the microbiota. Gut microbiota-microorganisms inhabiting the gastrointestinal tract-play crucial roles in health enhancement and can be modified via microbiome-based therapeutics-including probiotics-by strengthening the epithelial barrier, competitively excluding pathogens, and interacting with the brain-gut axis. It has been demonstrated that microbiota composition varies across different populations and is affected by multiple factors such as ethnicity, lifestyle, food availability, dietary habits, climate, and genetics. Because an individual's gut microbiome can influence drug absorption, distribution, metabolism, and excretion (ADME), it also plays a key role in determining probiotic efficacy. On the other hand, the characteristics of probiotics are influenced by both their genetic traits and environmental factors. Additionally, there are notable variations in probiotics regulations, strain-specific effects, commercial formulations, and probiotics sources among nations and geographical areas, which may have an impact on the viability of manufacturing probiotics products. Our paper will review the current knowledge on the relationship between geographical variation and probiotics efficacy. We believe that considering this relationship can be conducive to more accurate and rigorous product quality controls and play key role in progressing personalized approaches in microbiome-based therapies.

探索益生菌的区域差异:对功效和应用的影响。
益生菌是活的微生物,当给予足够的量时,对宿主的健康有益。这些细菌可以通过影响免疫系统成分、调节宿主信号和改变微生物群来影响健康状况。肠道微生物群-居住在胃肠道中的微生物-在增进健康方面发挥着至关重要的作用,可以通过基于微生物群的治疗方法(包括益生菌)进行修改,通过加强上皮屏障,竞争性地排除病原体,并与脑-肠轴相互作用。已经证明,微生物群的组成在不同的人群中有所不同,并受到种族、生活方式、食物供应、饮食习惯、气候和遗传等多种因素的影响。由于个体的肠道微生物组可以影响药物的吸收、分布、代谢和排泄(ADME),因此它在决定益生菌的功效方面也起着关键作用。另一方面,益生菌的特性受其遗传性状和环境因素的双重影响。此外,益生菌法规、菌株特异性效应、商业配方和益生菌来源在国家和地理区域之间存在显著差异,这可能会影响生产益生菌产品的可行性。本文将对地理变异与益生菌功效关系的最新研究进展进行综述。我们相信,考虑到这种关系有助于更准确和严格的产品质量控制,并在基于微生物组的治疗方法的个性化进展中发挥关键作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Microbial pathogenesis
Microbial pathogenesis 医学-免疫学
CiteScore
7.40
自引率
2.60%
发文量
472
审稿时长
56 days
期刊介绍: Microbial Pathogenesis publishes original contributions and reviews about the molecular and cellular mechanisms of infectious diseases. It covers microbiology, host-pathogen interaction and immunology related to infectious agents, including bacteria, fungi, viruses and protozoa. It also accepts papers in the field of clinical microbiology, with the exception of case reports. Research Areas Include: -Pathogenesis -Virulence factors -Host susceptibility or resistance -Immune mechanisms -Identification, cloning and sequencing of relevant genes -Genetic studies -Viruses, prokaryotic organisms and protozoa -Microbiota -Systems biology related to infectious diseases -Targets for vaccine design (pre-clinical studies)
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