Mohammad Abavisani, Niloofar Khoshroo, Pourya Tafti, Mohammad Akbari Moghadam, Prashant Kesharwani, Amirhossein Sahebkar
{"title":"Exploring regional variations in probiotics: Implications for efficacy and application.","authors":"Mohammad Abavisani, Niloofar Khoshroo, Pourya Tafti, Mohammad Akbari Moghadam, Prashant Kesharwani, Amirhossein Sahebkar","doi":"10.1016/j.micpath.2025.107963","DOIUrl":null,"url":null,"abstract":"<p><p>Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. These bacteria can affect health conditions by virtue of influencing immune system components, modulating of host signaling, and modifying the microbiota. Gut microbiota-microorganisms inhabiting the gastrointestinal tract-play crucial roles in health enhancement and can be modified via microbiome-based therapeutics-including probiotics-by strengthening the epithelial barrier, competitively excluding pathogens, and interacting with the brain-gut axis. It has been demonstrated that microbiota composition varies across different populations and is affected by multiple factors such as ethnicity, lifestyle, food availability, dietary habits, climate, and genetics. Because an individual's gut microbiome can influence drug absorption, distribution, metabolism, and excretion (ADME), it also plays a key role in determining probiotic efficacy. On the other hand, the characteristics of probiotics are influenced by both their genetic traits and environmental factors. Additionally, there are notable variations in probiotics regulations, strain-specific effects, commercial formulations, and probiotics sources among nations and geographical areas, which may have an impact on the viability of manufacturing probiotics products. Our paper will review the current knowledge on the relationship between geographical variation and probiotics efficacy. We believe that considering this relationship can be conducive to more accurate and rigorous product quality controls and play key role in progressing personalized approaches in microbiome-based therapies.</p>","PeriodicalId":18599,"journal":{"name":"Microbial pathogenesis","volume":" ","pages":"107963"},"PeriodicalIF":3.5000,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microbial pathogenesis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.micpath.2025.107963","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/7 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. These bacteria can affect health conditions by virtue of influencing immune system components, modulating of host signaling, and modifying the microbiota. Gut microbiota-microorganisms inhabiting the gastrointestinal tract-play crucial roles in health enhancement and can be modified via microbiome-based therapeutics-including probiotics-by strengthening the epithelial barrier, competitively excluding pathogens, and interacting with the brain-gut axis. It has been demonstrated that microbiota composition varies across different populations and is affected by multiple factors such as ethnicity, lifestyle, food availability, dietary habits, climate, and genetics. Because an individual's gut microbiome can influence drug absorption, distribution, metabolism, and excretion (ADME), it also plays a key role in determining probiotic efficacy. On the other hand, the characteristics of probiotics are influenced by both their genetic traits and environmental factors. Additionally, there are notable variations in probiotics regulations, strain-specific effects, commercial formulations, and probiotics sources among nations and geographical areas, which may have an impact on the viability of manufacturing probiotics products. Our paper will review the current knowledge on the relationship between geographical variation and probiotics efficacy. We believe that considering this relationship can be conducive to more accurate and rigorous product quality controls and play key role in progressing personalized approaches in microbiome-based therapies.
期刊介绍:
Microbial Pathogenesis publishes original contributions and reviews about the molecular and cellular mechanisms of infectious diseases. It covers microbiology, host-pathogen interaction and immunology related to infectious agents, including bacteria, fungi, viruses and protozoa. It also accepts papers in the field of clinical microbiology, with the exception of case reports.
Research Areas Include:
-Pathogenesis
-Virulence factors
-Host susceptibility or resistance
-Immune mechanisms
-Identification, cloning and sequencing of relevant genes
-Genetic studies
-Viruses, prokaryotic organisms and protozoa
-Microbiota
-Systems biology related to infectious diseases
-Targets for vaccine design (pre-clinical studies)