Comparative HLA Alleles and Haplotypes of Bone Marrow Volunteers Recruiting in the Asian and European Parts of Russia.

IF 4.1 4区医学 Q2 CELL BIOLOGY

HLA Pub Date : 2025-08-01 DOI:10.1111/tan.70350

Daria Smirnova, Maria Loginova, Olga Makhova, Ivan Obukhov, Igor Paramonov

引用次数: 0

Abstract

HLA typing of 9126 haematopoietic stem cell donors living in the Asian and European parts of Russia and identifying themselves as Russians was performed using NGS technology in 2-field resolution at the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci. The study of donors in the Asian part of Russia disclosed 77 alleles at the HLA-A locus, 111 at the HLA-B locus, 58 at the HLA-C locus, 54 at the HLA-DRB1 locus, and 26 at the HLA-DQB1 locus. Donors of the European part of Russia are characterised by the following allelic diversity: 87 alleles at the HLA-A locus, 136 at the HLA-B locus, 72 at the HLA-C locus, 67 at the HLA-DRB1 locus, and 37 at the HLA-DQB1 locus. The most common five-locus haplotype in both populations is HLA-A*01:01 ~ HLA-C*07:01 ~ HLA-B*08:01 ~ HLA-DRB1*03:01 ~ HLA-DQB1*02:01. Throughout the study, 26 new alleles were revealed.

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俄罗斯亚洲和欧洲地区招募的骨髓志愿者HLA等位基因和单倍型的比较

使用NGS技术对居住在俄罗斯亚洲和欧洲地区的9126名俄罗斯人造血干细胞供者在HLA- a、HLA- b、HLA- c、HLA- drb1和HLA- dqb1位点进行2场分辨率的HLA分型。对俄罗斯亚洲部分供体的研究发现HLA-A位点有77个等位基因，HLA-B位点有111个，HLA-C位点有58个，HLA-DRB1位点有54个，HLA-DQB1位点有26个。俄罗斯欧洲部分的供体具有以下等位基因多样性特征：HLA-A位点有87个等位基因，HLA-B位点有136个，HLA-C位点有72个，HLA-DRB1位点有67个，HLA-DQB1位点有37个。两种人群中最常见的五位点单倍型是HLA-A*01:01 ~ HLA-C*07:01 ~ HLA-B*08:01 ~ HLA-DRB1*03:01 ~ HLA-DQB1*02:01。在整个研究过程中，发现了26个新的等位基因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

HLA Immunology and Microbiology-Immunology

CiteScore

3.00

自引率

28.80%

发文量

368

期刊介绍： HLA, the journal, publishes articles on various aspects of immunogenetics. These include the immunogenetics of cell surface antigens, the ontogeny and phylogeny of the immune system, the immunogenetics of cell interactions, the functional aspects of cell surface molecules and their natural ligands, and the role of tissue antigens in immune reactions. Additionally, the journal covers experimental and clinical transplantation, the relationships between normal tissue antigens and tumor-associated antigens, the genetic control of immune response and disease susceptibility, and the biochemistry and molecular biology of alloantigens and leukocyte differentiation. Manuscripts on molecules expressed on lymphoid cells, myeloid cells, platelets, and non-lineage-restricted antigens are welcomed. Lastly, the journal focuses on the immunogenetics of histocompatibility antigens in both humans and experimental animals, including their tissue distribution, regulation, and expression in normal and malignant cells, as well as the use of antigens as markers for disease.