{"title":"Building and rebuilding complex tissues: strategic visions from a research-led workshop.","authors":"N Sumru Bayin, Benjamin Steventon, Mekayla Storer","doi":"10.1242/dev.205106","DOIUrl":null,"url":null,"abstract":"<p><p>How complex tissues develop and regenerate post-injury is one of the most fascinating and important processes in biology. Recent technical advances that enable the generation of a quantitative understanding of these processes have the potential to transform the field. However, to achieve this, concerted and long-term studies are required at the community level to compare regeneration and wound healing in both regenerative and non-regenerative contexts and organisms. To stimulate such collaboration, we recently organised a focused workshop around this topic to identify key outstanding questions that focus on cross-comparisons of regenerative competence, and the cellular, molecular and physical drivers of regeneration. Importantly, the discussions also highlighted significant logistical and financial challenges in initiating and sustaining large-scale, long-term interdisciplinary studies, particularly those involving non-model organisms.</p>","PeriodicalId":11375,"journal":{"name":"Development","volume":"152 20","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Development","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1242/dev.205106","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/7 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
How complex tissues develop and regenerate post-injury is one of the most fascinating and important processes in biology. Recent technical advances that enable the generation of a quantitative understanding of these processes have the potential to transform the field. However, to achieve this, concerted and long-term studies are required at the community level to compare regeneration and wound healing in both regenerative and non-regenerative contexts and organisms. To stimulate such collaboration, we recently organised a focused workshop around this topic to identify key outstanding questions that focus on cross-comparisons of regenerative competence, and the cellular, molecular and physical drivers of regeneration. Importantly, the discussions also highlighted significant logistical and financial challenges in initiating and sustaining large-scale, long-term interdisciplinary studies, particularly those involving non-model organisms.
期刊介绍：
Development’s scope covers all aspects of plant and animal development, including stem cell biology and regeneration. The single most important criterion for acceptance in Development is scientific excellence. Research papers (articles and reports) should therefore pose and test a significant hypothesis or address a significant question, and should provide novel perspectives that advance our understanding of development. We also encourage submission of papers that use computational methods or mathematical models to obtain significant new insights into developmental biology topics. Manuscripts that are descriptive in nature will be considered only when they lay important groundwork for a field and/or provide novel resources for understanding developmental processes of broad interest to the community.
Development includes a Techniques and Resources section for the publication of new methods, datasets, and other types of resources. Papers describing new techniques should include a proof-of-principle demonstration that the technique is valuable to the developmental biology community; they need not include in-depth follow-up analysis. The technique must be described in sufficient detail to be easily replicated by other investigators. Development will also consider protocol-type papers of exceptional interest to the community. We welcome submission of Resource papers, for example those reporting new databases, systems-level datasets, or genetic resources of major value to the developmental biology community. For all papers, the data or resource described must be made available to the community with minimal restrictions upon publication.
To aid navigability, Development has dedicated sections of the journal to stem cells & regeneration and to human development. The criteria for acceptance into these sections is identical to those outlined above. Authors and editors are encouraged to nominate appropriate manuscripts for inclusion in one of these sections.
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