Evaluation of intranasal dexmedetomidine on perioperative comfort evaluated using the General Comfort Questionnaire.

IF 2.2 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Current Medical Research and Opinion Pub Date : 2025-07-01 Epub Date: 2025-08-14 DOI:10.1080/03007995.2025.2545512
Jian Zheng, Fu-Qiang Chen, Yan Yang, Kang Wang, Jun Wang, Hai-Rong Gong
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Abstract

Objectives: Impaired clinical comfort has been shown to compromise in-hospital care quality and patient safety metrics. Therefore, optimizing perioperative comfort through evidence-based multimodal interventions has emerged as a paramount clinical priority in contemporary surgical and anesthesia practice. This study aimed to investigate the effects of intranasal administration of dexmedetomidine hydrochloride on comfort improvement in patients who underwent neuraxial anesthesia or nerve block anesthesia and to explore the risk factors for discomfort.

Methods: We retrospectively analyzed cohort data from 350 patients who underwent neuraxial anesthesia or nerve block anesthesia at Xuzhou Renci Hospital between January and September 2024. The patients were divided into a control group and a dexmedetomidine group on the basis of whether intranasal administration of dexmedetomidine hydrochloride was used. The primary endpoint was the General Comfort Questionnaire (GCQ) score after surgery. The secondary endpoints included the VAS score, the Pittsburgh Sleep Quality Index (PSQI) score, and changes in blood pressure and heart rate. A multivariable logistic regression model was used to screen for risk factors associated with discomfort.

Results: In this study, 200 patients underwent conventional anesthesia, and the remaining 150 patients were first administered dexmedetomidine hydrochloride intranasally before anesthesia induction. At various time points after surgery, the GCQ scores of patients in the dexmedetomidine group were consistently higher than those of patients in the control group (p < 0.001). The mean arterial blood pressure, heart rate, PSQI score, and VAS score were lower in the dexmedetomidine group than in the control group (p < 0.001). In the multivariable analysis, intervention (OR, 0.01; 95% CI, 0.00-0.05), age (OR, 1.17; 95% CI, 1.11-1.24), male sex (OR, 0.62; 95% CI, 0.41-0.95), sleep quality (OR, 1.57; 95% CI, 1.38-1.79) and pain catastrophizing scale score (OR, 1.08; 95% CI, 1.02-1.14) were independently associated with the GCQ score.

Conclusions: These findings indicate that intranasal administration of dexmedetomidine hydrochloride significantly enhanced patient comfort, as evidenced by elevated GCQ scores, reduced VAS scores, and significantly improved postoperative sleep quality. Age, sex, sleep quality and pain catastrophizing scale scores were found to be independent factors for discomfort.

使用一般舒适度问卷评估鼻内右美托咪定对围手术期舒适度的影响。
目的:临床舒适度受损已被证明会损害院内护理质量和患者安全指标。因此,通过循证多模式干预优化围手术期舒适度已成为当代外科和麻醉实践中最重要的临床重点。本研究旨在探讨经鼻给药盐酸右美托咪定对神经阻滞或轴向麻醉患者舒适度的改善作用,并探讨引起不适的危险因素。方法:回顾性分析2024年1 - 9月在徐州市仁慈医院行轴麻或神经阻滞麻醉的350例患者的队列资料。根据是否鼻内给药盐酸右美托咪定分为对照组和右美托咪定组。主要终点是术后一般舒适问卷(GCQ)评分。次要终点包括VAS评分、匹兹堡睡眠质量指数(PSQI)评分、血压和心率的变化。采用多变量logistic回归模型筛选与不适相关的危险因素。结果:本研究中200例患者采用常规麻醉,其余150例患者在麻醉诱导前先鼻内给予盐酸右美托咪定。在术后各时间点,右美托咪定组患者的GCQ评分均高于对照组(P P)。结论:盐酸右美托咪定鼻内给药可显著提高患者舒适度,GCQ评分升高,VAS评分降低,术后睡眠质量明显改善。年龄、性别、睡眠质量和疼痛灾难量表得分被发现是不舒服的独立因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Medical Research and Opinion
Current Medical Research and Opinion 医学-医学:内科
CiteScore
4.40
自引率
4.30%
发文量
247
审稿时长
3-8 weeks
期刊介绍: Current Medical Research and Opinion is a MEDLINE-indexed, peer-reviewed, international journal for the rapid publication of original research on new and existing drugs and therapies, Phase II-IV studies, and post-marketing investigations. Equivalence, safety and efficacy/effectiveness studies are especially encouraged. Preclinical, Phase I, pharmacoeconomic, outcomes and quality of life studies may also be considered if there is clear clinical relevance
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