Research Progress on the Mechanisms of Traditional Chinese Medicine in Preventing and Treating HCC Invasion and Metastasis Based on Lipid Metabolic Reprogramming.

IF 3.3 4区 医学 Q3 CHEMISTRY, MEDICINAL
Mengke Wang, Hanning Lyu, Yuxin Liu, Yang Sun
{"title":"Research Progress on the Mechanisms of Traditional Chinese Medicine in Preventing and Treating HCC Invasion and Metastasis Based on Lipid Metabolic Reprogramming.","authors":"Mengke Wang, Hanning Lyu, Yuxin Liu, Yang Sun","doi":"10.2174/0115680266366687250730060318","DOIUrl":null,"url":null,"abstract":"<p><p>Hepatocellular Carcinoma (HCC) represents a common malignant tumor worldwide, having a profound effect on human health. The processes of invasion and spreading to distant sites are critical malignant biological behaviors exhibited by tumors. The metabolic environment is intricately linked to the initiation, invasion, and subsequent dissemination of tumor cells, with a particular emphasis on lipid metabolism. Lipid metabolism plays a vital role in mediating membrane structure, providing energy, and facilitating signal transduction. It not only delivers energy sources for tumor cells but also establishes conditions conducive to the initiation, progression, and spread of HCC. To meet their energy demands, tumor cells undergo a process of lipid metabolic reprogramming, characterized here as abnormal lipid metabolism. Therefore, a comprehensive investigation into the mechanisms underpinning lipid metabolic reprogramming and its influence on HCC growth and dissemination is crucial for the prevention, early detection, and identification of novel therapeutic targets for HCC. This article initially delineates the metabolic pathways of fatty acids within cells during the development and progression of HCC. It then reviews recent advancements in understanding abnormal lipid metabolism, focusing on the associated genes, enzymes, proteins, and metabolic products that promote HCC progression and spread. Furthermore, a brief overview of the Tumor Immune Microenvironment (TIME) in HCC is provided, highlighting the interactions between Tumor-Associated Macrophages (TAMs) and HCC lipid metabolic reprogramming, as well as their effects on HCC growth and dissemination. Lastly, it examines the treatments targeting abnormal lipid metabolism in HCC utilizing Traditional Chinese Medicine (TCM) and natural products, offering new perspectives for targeting HCC lipid metabolic reprogramming to inhibit spread and invasion.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current topics in medicinal chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0115680266366687250730060318","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0

Abstract

Hepatocellular Carcinoma (HCC) represents a common malignant tumor worldwide, having a profound effect on human health. The processes of invasion and spreading to distant sites are critical malignant biological behaviors exhibited by tumors. The metabolic environment is intricately linked to the initiation, invasion, and subsequent dissemination of tumor cells, with a particular emphasis on lipid metabolism. Lipid metabolism plays a vital role in mediating membrane structure, providing energy, and facilitating signal transduction. It not only delivers energy sources for tumor cells but also establishes conditions conducive to the initiation, progression, and spread of HCC. To meet their energy demands, tumor cells undergo a process of lipid metabolic reprogramming, characterized here as abnormal lipid metabolism. Therefore, a comprehensive investigation into the mechanisms underpinning lipid metabolic reprogramming and its influence on HCC growth and dissemination is crucial for the prevention, early detection, and identification of novel therapeutic targets for HCC. This article initially delineates the metabolic pathways of fatty acids within cells during the development and progression of HCC. It then reviews recent advancements in understanding abnormal lipid metabolism, focusing on the associated genes, enzymes, proteins, and metabolic products that promote HCC progression and spread. Furthermore, a brief overview of the Tumor Immune Microenvironment (TIME) in HCC is provided, highlighting the interactions between Tumor-Associated Macrophages (TAMs) and HCC lipid metabolic reprogramming, as well as their effects on HCC growth and dissemination. Lastly, it examines the treatments targeting abnormal lipid metabolism in HCC utilizing Traditional Chinese Medicine (TCM) and natural products, offering new perspectives for targeting HCC lipid metabolic reprogramming to inhibit spread and invasion.

基于脂质代谢重编程的中药防治肝癌侵袭转移机制研究进展
肝细胞癌(HCC)是世界范围内常见的恶性肿瘤,对人类健康有着深远的影响。肿瘤的侵袭和远处扩散过程是肿瘤表现出的重要的恶性生物学行为。代谢环境与肿瘤细胞的起始、侵袭和随后的传播有着复杂的联系,尤其是脂质代谢。脂质代谢在调节细胞膜结构、提供能量、促进信号转导等方面发挥着重要作用。它不仅为肿瘤细胞提供能量来源,而且为HCC的发生、发展和扩散创造有利条件。为了满足它们的能量需求,肿瘤细胞经历了脂质代谢重编程过程,这里的特征是脂质代谢异常。因此,全面研究脂质代谢重编程的机制及其对HCC生长和传播的影响对于预防、早期发现和确定HCC的新治疗靶点至关重要。本文初步描述了肝癌发生发展过程中脂肪酸在细胞内的代谢途径。然后回顾了在理解异常脂质代谢方面的最新进展,重点关注促进HCC进展和扩散的相关基因、酶、蛋白质和代谢产物。此外,本文还简要概述了HCC中的肿瘤免疫微环境(TIME),重点介绍了肿瘤相关巨噬细胞(tam)与HCC脂质代谢重编程之间的相互作用,以及它们对HCC生长和传播的影响。最后,探讨了针对HCC脂质代谢异常的中药和天然产物的治疗方法,为针对HCC脂质代谢重编程抑制扩散和侵袭提供了新的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
6.40
自引率
2.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信