S-Nitrosylation: Mechanistic Links between Nitric Oxide Signaling and Atherosclerosis.

IF 5.2 2区医学 Q1 PERIPHERAL VASCULAR DISEASE

Current Atherosclerosis Reports Pub Date : 2025-08-07 DOI:10.1007/s11883-025-01321-y

Weixiong Xu, Daniel Chen, Hua-Lin Zhou

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引用次数: 0

Abstract

Purpose of review: This review explores current knowledge on the beneficial and detrimental roles of nitric oxide (NO) in vascular biology, with a particular focus on the emerging role of protein S-nitrosylation in the pathophysiology of atherosclerosis.

Recent findings: Major risk factors for atherosclerosis include hypercholesterolemia, low-density lipoprotein (LDL) oxidation, hyperglycemia, hyperhomocysteinemia, chronic inflammation, and obesity. Recent studies have shown that protein S-nitrosylation interacts with these risk factors, influencing atherogenesis either by promoting or inhibiting disease progression. Atherosclerosis is a chronic inflammatory disorder marked by the accumulation of plaques within arterial walls, arising from intricate interactions among endothelial cells, monocytes/macrophages, and vascular smooth muscle cells. Understanding the role of S-nitrosylation in regulating key cellular events-such as endothelial dysfunction, foam cell formation, and vascular smooth muscle cell proliferation-offers new insights into the molecular mechanisms underlying atherosclerosis. These insights may ultimately lead to the identification of novel therapeutic targets for cardiovascular disease.

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s -亚硝基化：一氧化氮信号与动脉粥样硬化之间的机制联系。

综述目的：本文综述了目前关于一氧化氮（NO）在血管生物学中的有益和有害作用的知识，特别关注了蛋白质s -亚硝基化在动脉粥样硬化病理生理中的新作用。最近发现：动脉粥样硬化的主要危险因素包括高胆固醇血症、低密度脂蛋白（LDL）氧化、高血糖、高同型半胱氨酸血症、慢性炎症和肥胖。最近的研究表明，蛋白质s -亚硝基化与这些危险因素相互作用，通过促进或抑制疾病进展影响动脉粥样硬化的发生。动脉粥样硬化是一种慢性炎症性疾病，其特征是动脉壁内斑块的积累，由内皮细胞、单核/巨噬细胞和血管平滑肌细胞之间复杂的相互作用引起。了解s-亚硝基化在调节关键细胞事件（如内皮功能障碍、泡沫细胞形成和血管平滑肌细胞增殖）中的作用，为动脉粥样硬化的分子机制提供了新的见解。这些见解可能最终导致心血管疾病的新治疗靶点的确定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Atherosclerosis Reports 医学-

CiteScore

9.00

自引率

3.40%

发文量

审稿时长

6-12 weeks

期刊介绍： The aim of this journal is to systematically provide expert views on current basic science and clinical advances in the field of atherosclerosis and highlight the most important developments likely to transform the field of cardiovascular prevention, diagnosis, and treatment. We accomplish this aim by appointing major authorities to serve as Section Editors who select leading experts from around the world to provide definitive reviews on key topics and papers published in the past year. We also provide supplementary reviews and commentaries from well-known figures in the field. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.