Interleukin-6 as a Predictive Marker for Lymph Node and Distant Metastasis in Colorectal Cancer: A Retrospective Cohort Study.

IF 2.6 4区医学 Q3 ONCOLOGY

Cancer Management and Research Pub Date : 2025-08-01 eCollection Date: 2025-01-01 DOI:10.2147/CMAR.S527441

Jianjun Xiao, Muyou Tian, Guoyu Chen, Huifen Li

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Abstract

Background: Metastasis is the leading cause of death in colorectal cancer (CRC). While interleukin-6 (IL-6), a key inflammatory cytokine, is implicated in tumor metastasis, its specific association with lymph node metastasis (LNM) and distant metastasis (DM) in CRC remains unclear.

Methods: We retrospectively analyzed clinical data and serum levels of carcinoembryonic antigen (CEA) and cytokines (including IL-6) in 427 CRC patients, stratified by metastatic status. Statistical analyses assessed the predictive value of IL-6 for metastasis.

Results: Elevated serum IL-6 levels were significantly associated with both LNM and DM (P<0.05). IL-6 positively correlated with CEA levels (Spearman correlation). Although IL-6 alone showed modest predictive power for LNM (AUC=0.555), it outperformed CEA (AUC=0.525). Combining IL-6 and CEA improved diagnostic accuracy for LNM (AUC=0.583). Notably, IL-6 demonstrated greater sensitivity than CEA in predicting DM (77.30% vs 67.40% at optimal cutoff).

Conclusion: These findings demonstrate that IL-6 holds significant predictive value for metastasis in CRC, particularly excelling in the prediction of LNM. The detection of IL-6 offers a valuable complementary approach to the existing clinical prediction paradigm for CRC metastasis risk.

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白介素-6作为结直肠癌淋巴结和远处转移的预测标志物：一项回顾性队列研究

背景：转移是结直肠癌（CRC）死亡的主要原因。虽然白细胞介素-6 （IL-6）是一种关键的炎症细胞因子，与肿瘤转移有关，但其与结直肠癌淋巴结转移（LNM）和远处转移（DM）的具体关系尚不清楚。方法：我们回顾性分析427例CRC患者的临床资料和血清癌胚抗原（CEA）和细胞因子（包括IL-6）水平，并按转移状态分层。统计学分析评估了IL-6对转移的预测价值。结果：血清IL-6水平升高与LNM和DM均有显著相关性(p)。结论：这些结果表明IL-6对结直肠癌转移具有重要的预测价值，特别是对LNM的预测效果更好。IL-6的检测为现有的结直肠癌转移风险临床预测模式提供了一种有价值的补充方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Management and Research Medicine-Oncology

CiteScore

7.40

自引率

0.00%

发文量

448

审稿时长

16 weeks

期刊介绍： Cancer Management and Research is an international, peer reviewed, open access journal focusing on cancer research and the optimal use of preventative and integrated treatment interventions to achieve improved outcomes, enhanced survival, and quality of life for cancer patients. Specific topics covered in the journal include: ◦Epidemiology, detection and screening ◦Cellular research and biomarkers ◦Identification of biotargets and agents with novel mechanisms of action ◦Optimal clinical use of existing anticancer agents, including combination therapies ◦Radiation and surgery ◦Palliative care ◦Patient adherence, quality of life, satisfaction The journal welcomes submitted papers covering original research, basic science, clinical & epidemiological studies, reviews & evaluations, guidelines, expert opinion and commentary, and case series that shed novel insights on a disease or disease subtype.