{"title":"Small Duodenal Adenocarcinoma with Peritoneal Dissemination Mimicking Duodenal Brunner's Gland Hyperplasia.","authors":"Masao Yoshida, Yoichi Yamamoto, Hiroyuki Ono","doi":"10.1159/000547237","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Gastric-phenotype non-ampullary duodenal carcinomas are rare but potentially aggressive tumors.</p><p><strong>Case presentation: </strong>A 52-year-old woman was referred for a duodenal polyp. Endoscopy revealed multiple duodenal bulb polyps suggestive of Brunner's gland hyperplasia. Histopathology confirmed well-differentiated tubular adenocarcinoma with submucosal invasion and a positive margin. The patient underwent pancreaticoduodenectomy, and residual subserosal carcinoma was detected. Despite adjuvant chemotherapy, liver metastases and peritoneal dissemination developed 7 months postoperatively. The patient died 24 months after surgery.</p><p><strong>Conclusion: </strong>This case highlights the aggressive nature of gastric-phenotype duodenal adenocarcinoma and the need for early radical surgical intervention when vertical margins are positive after endoscopic resection.</p>","PeriodicalId":9625,"journal":{"name":"Case Reports in Oncology","volume":"18 1","pages":"1069-1073"},"PeriodicalIF":0.7000,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12327926/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Case Reports in Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000547237","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Gastric-phenotype non-ampullary duodenal carcinomas are rare but potentially aggressive tumors.
Case presentation: A 52-year-old woman was referred for a duodenal polyp. Endoscopy revealed multiple duodenal bulb polyps suggestive of Brunner's gland hyperplasia. Histopathology confirmed well-differentiated tubular adenocarcinoma with submucosal invasion and a positive margin. The patient underwent pancreaticoduodenectomy, and residual subserosal carcinoma was detected. Despite adjuvant chemotherapy, liver metastases and peritoneal dissemination developed 7 months postoperatively. The patient died 24 months after surgery.
Conclusion: This case highlights the aggressive nature of gastric-phenotype duodenal adenocarcinoma and the need for early radical surgical intervention when vertical margins are positive after endoscopic resection.
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