Multimodal PAI/OCT Imaging System for Precision Diagnosis and Therapy in Atopic Dermatitis: A Pilot Study.

IF 2.3
Jiayi Yang, Qi Chen, Chunxiao Li, Jingjuan Shi, Peiru Wang, Xiuli Wang
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引用次数: 0

Abstract

Atopic dermatitis (AD), a chronic inflammatory skin disorder, faces diagnostic limitations due to subjective clinical assessments. This study introduces an integrated photoacoustic imaging (PAI)/optical coherence tomography (OCT) system for noninvasive, quantitative evaluation of MC903-induced AD-like dermatitis in mice and Crisaborole efficacy. Multimodal imaging demonstrated Crisaborole's suppression of pathological angiogenesis (50.7% fewer vascular junctions, 23% reduced density, 47% shorter vessel length) and tissue remodeling (20% epidermal thinning, 23% signal decline), validated by histopathology. The system captured in vivo dynamic vascular network restructuring and epidermal alterations during AD progression, revealing temporal links between angiogenesis, hyperplasia, and inflammation. PAI/OCT synergistically provides complementary functional-structural biomarkers, advancing precision diagnosis and therapy in AD models. This work pioneers real-time monitoring of AD pathophysiology, supporting clinical translation through quantitative multiparametric characterization for tailored therapeutic strategies.

多模态PAI/OCT成像系统用于特应性皮炎的精确诊断和治疗:一项初步研究。
特应性皮炎(AD)是一种慢性炎症性皮肤病,由于主观临床评估而面临诊断局限性。本研究介绍了一种集成光声成像(PAI)/光学相干断层扫描(OCT)系统,用于无创、定量评估mc903诱导的小鼠ad样皮炎和Crisaborole的疗效。多模式成像显示Crisaborole抑制病理性血管生成(50.7%的血管连接减少,23%的密度降低,47%的血管长度缩短)和组织重塑(20%的表皮变薄,23%的信号下降),经组织病理学证实。该系统捕获了AD进展过程中体内动态血管网络重构和表皮改变,揭示了血管生成、增生和炎症之间的时间联系。PAI/OCT协同提供互补的功能结构生物标志物,推进AD模型的精确诊断和治疗。这项工作开创了实时监测阿尔茨海默病病理生理的先机,通过定量多参数表征为量身定制的治疗策略支持临床翻译。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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