Incidence of first hospitalization for heart failure in type 2 diabetes mellitus: A population-based cohort study in primary care

IF 2.3 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Primary Care Diabetes Pub Date : 2025-08-05 DOI:10.1016/j.pcd.2025.07.009

Miguel-Angel Muñoz , Victoria Cendrós , Elena Navas , Jose-Maria Verdú-Rotellar , Joan Barrot , Josep Franch

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引用次数: 0

Abstract

Objectives

To analyse the incidence of first hospitalization for heart failure (HF) in a cohort of patients newly diagnosed with type 2 diabetes mellitus (T2DM) compared with those without T2DM, attended in primary care.

Participants

Retrospective cohort study including both the entire adult population of Catalonia who developed T2DM (N = 518,232), and three paired controls for each of them (N = 1503,812), followed between January 2010 and December 2023. Patients’ characteristics and diagnostics were drawn from the System for the Development of Research in Primary Care (SIDIAP) database. Information on the first hospitalization was obtained from the hospital discharge database (CMBD).

Primary and secondary outcome measures

We analysed the incidence of first hospitalization for HF.

Results

Over the 13-year period of the study, there were 24,565 (4.7 %) and 25,886 (1.7 %) episodes of first hospitalization for HF among those with and without T2DM, respectively. In patients with incident T2DM we found that hypertension (HR 8.59; 95 % CI 7.41 – 9.96), atrial fibrillation (HR 2.30; 95 % CI 2.15 – 2.45) and ischemic heart disease (HR 1.61; 95 %CI 1.50 – 1.72) were the main predictors of first hospitalization for HF. Chronic kidney disease, age, male sex, obesity, dyslipidemia, and global comorbidity, also contributed to the risk of incident heart failure.

Conclusions

Incidence of first hospitalization for HF in patients newly diagnosed with T2DM, attended in primary care is three-fold higher than in those without T2DM. This Incidence remains stable in spite of new therapeutic approaches.

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2型糖尿病患者因心力衰竭首次住院的发生率：一项基于人群的初级保健队列研究

目的：分析一组新诊断为2型糖尿病（T2DM）的患者因心力衰竭（HF）首次住院的发生率，并与未诊断为T2DM的患者进行比较。参与者：回顾性队列研究，包括加泰罗尼亚发生T2DM的整个成年人群（N = 518,232），以及每个人的三个配对对照（N = 1503,812），随访时间为2010年1月至2023年12月。患者的特征和诊断来自初级保健研究发展系统（SIDIAP）数据库。首次住院的信息来自出院数据库（CMBD）。主要和次要结局指标我们分析了心衰首次住院的发生率。结果：在13年的研究期间，有2型糖尿病和无2型糖尿病的HF患者分别有24,565例（4.7 %）和25,886例（1.7 %）首次住院。在T2DM患者中，我们发现高血压(HR 8.59；95 % CI 7.41 - 9.96)，心房颤动(HR 2.30；95 % CI 2.15 - 2.45)和缺血性心脏病(HR 1.61；95 %CI 1.50 ~ 1.72)是HF首次住院的主要预测因子。慢性肾脏疾病、年龄、男性、肥胖、血脂异常和整体合并症也会增加心力衰竭的发生风险。结论：初诊T2DM患者因HF首次住院的发生率比非T2DM患者高3倍。尽管采用了新的治疗方法，这一发病率仍保持稳定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Primary Care Diabetes ENDOCRINOLOGY & METABOLISM-PRIMARY HEALTH CARE

CiteScore

5.00

自引率

3.40%

发文量

134

审稿时长

47 days

期刊介绍： The journal publishes original research articles and high quality reviews in the fields of clinical care, diabetes education, nutrition, health services, psychosocial research and epidemiology and other areas as far as is relevant for diabetology in a primary-care setting. The purpose of the journal is to encourage interdisciplinary research and discussion between all those who are involved in primary diabetes care on an international level. The Journal also publishes news and articles concerning the policies and activities of Primary Care Diabetes Europe and reflects the society''s aim of improving the care for people with diabetes mellitus within the primary-care setting.