Christopher Paisey, Christy Kaiyamo, Chun Lap Pang, Gurjit Chohan
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引用次数: 0
Abstract
Patients with predominantly neurological symptoms and signs as their first manifestation of diffuse large B cell lymphoma (DLBCL) represent a diagnostic challenge. We present the clinical course, imaging findings and postmortem pathological correlates of a patient first presenting to neurology with symptoms relating to DLBCL. He died before confirmation of the diagnosis despite early suspicion of central nervous system (CNS) lymphoma and relevant investigation. The diagnosis was confirmed at postmortem by immunohistochemistry of spinal and brain lesions. MRI showing CNS lesions consistent with demyelination is common and lymphoma is rarely the cause. However, when there is high clinical suspicion, tissue diagnosis should be sought whether by skin, lymph node or brain biopsy.
期刊介绍：
The essential point of Practical Neurology is that it is practical in the sense of being useful for everyone who sees neurological patients and who wants to keep up to date, and safe, in managing them. In other words this is a journal for jobbing neurologists - which most of us are for at least part of our time - who plough through the tension headaches and funny turns week in and week out. Primary research literature potentially relevant to routine clinical practice is far too much for any neurologist to read, let alone understand, critically appraise and assimilate. Therefore, if research is to influence clinical practice appropriately and quickly it has to be digested and provided to neurologists in an informative and convenient way.
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