Risk factors of lower urinary tract symptoms measured by the International Consultation on Incontinence Modular Questionnaire in females with lupus cystitis: A case-control study.

IF 1.3 4区 医学 Q4 UROLOGY & NEPHROLOGY
Current Urology Pub Date : 2025-07-01 Epub Date: 2025-02-26 DOI:10.1097/CU9.0000000000000276
Amr Abou Faddan, Rabea Ahmed Gadelkareem, Manal Hassanien, Hassan Abdellatif Abolella, Esraa Ahmed Talaat
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引用次数: 0

Abstract

Background: Lupus cystitis may cause significant lower urinary tract symptoms (LUTS). This study aimed to evaluate LUTS and identify potential risk factors in female patients with systemic lupus erythematosus (SLE).

Materials and methods: In this case-control study, 46 female patients with SLE were assessed for LUTS using the International Consultation on Incontinence Modular Questionnaire on Female Lower Urinary Tract Symptoms (ICIQ-FLUTS). The findings were compared with a control group of 20 women.

Results: The total incidence rates of LUTS in the SLE and control groups were 82.6% and 55%, respectively (p = 0.022). Statistically significant differences were observed between the 2 groups in symptom duration (p < 0.001), filling (p < 0.001), voiding (p = 0.001), incontinence (p < 0.001), and total LUTS scores (p < 0.001) as measured by ICIQ-FLUTS. Additional significant differences included renal echogenicity (p = 0.003), bladder wall thickness (p = 0.045), and the presence of pus cells in urine (p = 0.045). The possible risk factors for the occurrence of LUTS in patients with lupus cystitis included rapid weight loss (p = 0.025), easy fatigability (p = 0.006), fever (p = 0.046), psychosis (p = 0.033), and both renal (p = 0.025) and clinical (p = 0.047) SLE disease activity indices. The Spearman correlation between the total ICIQ-FLUTS score and the SLE Disease Activity Index was not significant (r = -0.203; p = 0.181). However, a statistically significant but weak correlation was observed between the ICIQ-FLUTS score and easy fatigability (r = 0.381; p = 0.013).

Conclusions: The ICIQ-FLUTS demonstrated acceptable content validity and consistency in evaluating LUTS in patients with lupus cystitis. Rapid weight loss, easy fatigability, fever, psychosis, and elevated renal and clinical SLE Disease Activity Index scores were significantly associated with the occurrence of LUTS in these patients.

狼疮性膀胱炎女性患者下尿路症状的危险因素:一项病例对照研究。
背景:狼疮性膀胱炎可引起明显的下尿路症状(LUTS)。本研究旨在评估女性系统性红斑狼疮(SLE)患者的LUTS并确定其潜在危险因素。材料和方法:在本病例对照研究中,使用国际失禁女性下尿路症状模块问卷(ICIQ-FLUTS)对46例女性SLE患者进行LUTS评估。研究人员将研究结果与对照组的20名女性进行了比较。结果:SLE组和对照组LUTS的总发病率分别为82.6%和55% (p = 0.022)。两组患者在症状持续时间(p < 0.001)、充血(p < 0.001)、排尿(p = 0.001)、尿失禁(p < 0.001)和ICIQ-FLUTS总分(p < 0.001)方面差异均有统计学意义。其他显著差异包括肾脏回声增强(p = 0.003)、膀胱壁厚度(p = 0.045)和尿液中脓细胞的存在(p = 0.045)。狼疮性膀胱炎患者发生LUTS的可能危险因素包括体重迅速减轻(p = 0.025)、易疲劳(p = 0.006)、发热(p = 0.046)、精神状态(p = 0.033)以及肾脏(p = 0.025)和临床(p = 0.047) SLE疾病活动性指标。ICIQ-FLUTS总分与SLE疾病活动指数的Spearman相关性不显著(r = -0.203;P = 0.181)。然而,ICIQ-FLUTS评分与易疲劳性之间存在统计学上显著但较弱的相关性(r = 0.381;P = 0.013)。结论:ICIQ-FLUTS在评估狼疮膀胱炎患者的LUTS方面具有可接受的内容效度和一致性。体重迅速减轻、易疲劳、发热、精神失常、肾脏和临床SLE疾病活动指数评分升高与这些患者LUTS的发生显著相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Urology
Current Urology Medicine-Urology
CiteScore
2.30
自引率
0.00%
发文量
96
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