Protein intake and insulin-like growth factor-1 at 12 months and associations with growth, body composition, and metabolic syndrome at 8 years.

IF 2.6 3区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI:10.1002/jpn3.70179

Gabriella O Seidal, Jovanna Dahlgren, Stefan Bergman, Gerd A Tangen, Josefine Roswall

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引用次数: 0

Abstract

Objectives: Metabolic programming may occur during early life and have long-lasting effects on metabolic health. This study examined what impact early protein intake and levels of insulin-like growth factor (IGF-1) at 1 year of age had on growth, body composition and risk factors for metabolic syndrome at 8 years of age.

Methods: This was a prospective, observational, population-based study of 551 healthy, Swedish children. We used food diaries handed in at 1 year of age, and IGF-1 was measured at the same age. At 8 years of age, the children attended a clinical visit, where they underwent a dual X-ray absorptiometry scan, blood sampling, and anthropometry measurements.

Results: Protein intake at 1 year of age was associated with high waist circumference and insulin resistance measured as homeostatic model assessment for insulin resistance, at 8 years of age.

Conclusions: Protein intake at 1 year of age may have an impact on later metabolic health, mainly in form of insulin resistance and waist circumference.

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12个月时蛋白质摄入量和胰岛素样生长因子-1与8岁时生长、身体成分和代谢综合征的关系。

目的：代谢编程可能发生在生命早期，并对代谢健康有长期影响。这项研究调查了1岁时早期蛋白质摄入量和胰岛素样生长因子（IGF-1）水平对8岁时生长、身体成分和代谢综合征风险因素的影响。方法：这是一项前瞻性、观察性、基于人群的研究，研究对象为551名健康的瑞典儿童。我们使用了1岁时提交的食物日记，并在同一年龄测量了IGF-1。在8岁时，孩子们参加了一次临床访问，在那里他们接受了双x线吸收扫描，血液采样和人体测量。结果：1岁时的蛋白质摄入量与高腰围和8岁时的胰岛素抵抗相关，作为胰岛素抵抗的稳态模型评估。结论：1岁时蛋白质摄入可能对后期代谢健康产生影响，主要表现为胰岛素抵抗和腰围。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pediatric Gastroenterology and Nutrition 医学-胃肠肝病学

CiteScore

5.30

自引率

13.80%

发文量

467

审稿时长

3-6 weeks

期刊介绍： The Journal of Pediatric Gastroenterology and Nutrition (JPGN) provides a forum for original papers and reviews dealing with pediatric gastroenterology and nutrition, including normal and abnormal functions of the alimentary tract and its associated organs, including the salivary glands, pancreas, gallbladder, and liver. Particular emphasis is on development and its relation to infant and childhood nutrition.