Screening for Term Preeclampsia at 35 to 37 Weeks of Gestation: A Single-Center Experience.

IF 1.6 3区医学 Q3 OBSTETRICS & GYNECOLOGY

Fetal Diagnosis and Therapy Pub Date : 2025-08-05 DOI:10.1159/000547694

Selina Manuela Diethelm, Thabea Musik, Cécile Monod, Lysann Hildebrandt, Olav Lapaire, Gwendolin Manegold-Brauer, Sofia Amylidi-Mohr, Beatrice Mosimann

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引用次数: 0

Abstract

Introduction: Prevention of preeclampsia has short- and long-term benefits for maternal health. Recent data suggest that combined screening at 35-37 weeks of gestation with anamnestic risk factors, mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), and angiogenic profile (sFlt-1/PlGF) detects up to 80% of all tPE. The aim of this retrospective analysis was to test the performance of third-trimester screening for tPE in a single center in Switzerland.

Methods: Singleton pregnancies with complete background risk assessments, MAP, and, if available, UtA-PI and sFlt-1/PlGF from 2018 to 2023 were included and risks were calculated on the FMF London website.

Results: 1,121 pregnancies, including 22 (2.0%) with tPE, were analyzed. Median MAP-MoM [IQR] in tPE was 1.08 [1.00-1.14], compared to 0.98 [0.92-1.04] in controls (p < 0.0001). Median UtA-PI-MoM [IQR] in tPE was 1.04 [0.85-1.27] versus 0.99 [0.82-1.15] (p = 0.56). No sFlt-1/PlGF recordings in tPE were available for analysis. The detection rate in combined screening was 15/22 (68.2%) compared to screening by anamnestic risk factors only of 9/22 (40.9%).

Conclusion: This analysis shows that combined screening at 35-37 weeks of gestation including anamnestic risk factors and MAP performs better than screening by anamnestic risk factors alone. These results should further be verified in a prospective trial including all markers.

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在妊娠35至37周筛查足月先兆子痫-单中心经验。

导读：预防先兆子痫对孕产妇健康有短期和长期的好处。最近的数据表明，在妊娠35至37周时，结合健忘危险因素、平均动脉压（MAP）、子宫动脉搏动指数（UtA-PI）和血管生成谱（sFlt-1/PlGF）进行联合筛查，可检测到80%的所有类型的pe。本回顾性分析的目的是在瑞士的一个单一中心测试妊娠晚期tPE筛查的表现。方法：纳入2018年至2023年进行完整背景风险评估、MAP以及可用的UtA-PI和sFlt-1/PlGF的单胎妊娠，并在伦敦FMF网站上计算风险。结果：分析1121例妊娠，其中22例（2.0%）为tPE。tPE组MAP- mom [IQR]中位数为1.08[1.00-1.14]，对照组为0.98[0.92-1.04]。结论：在妊娠35-37周联合筛查健忘危险因素和MAP优于单独筛查健忘危险因素。这些结果应在包括所有标记物的前瞻性试验中进一步验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fetal Diagnosis and Therapy 医学-妇产科学

CiteScore

4.70

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： The first journal to focus on the fetus as a patient, ''Fetal Diagnosis and Therapy'' provides a wide range of biomedical specialists with a single source of reports encompassing the common discipline of fetal medicine.