Long-term survival outcomes of proximal gastrectomy versus total gastrectomy in patients with T2-3 esophagogastric junction adenocarcinoma and upper third gastric adenocarcinoma: a propensity score-matching analysis.

IF 4.2 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Gastroenterology Report Pub Date : 2025-08-04 eCollection Date: 2025-01-01 DOI:10.1093/gastro/goaf071

Yi Liao, Hao Chen, Jun Xiang, Jintuan Huang, Chunyu Chen, Zuli Yang

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引用次数: 0

Abstract

Background: We aimed to investigate long-term survival outcome in patients with locally advanced esophagogastric junction adenocarcinoma and upper third gastric adenocarcinoma (EGJ-UG adenocarcinoma) who underwent proximal gastrectomy (PG) or total gastrectomy (TG).

Methods: We searched and analyzed the data from the Surveillance, Epidemiology, and End Results (SEER) database. Patients with T2-3 EGJ-UG adenocarcinoma receiving TG or PG were included. We performed a propensity score 1:2 matching, and matched datasets were generated and compared.We obtained the patients' long-term survival benefits according to stratification of surgical approaches.

Results: Of 1,291 patients identified from the SEER database, 901 (69.8%) patients received PG and 390 (30.2%) patients received TG. After matching, 584 patients in the PG group were matched by propensity score to 344 patients in the TG group. There were no differences in overall survival and cancer-specific survival in matched data between different surgical approaches. For patients with tumor size ≤4 cm, similar long-term survival was observed in patients receiving PG and TG. For patients with tumor size >4 cm, TG was associated with improved overall survival and cancer-specific survival compared with PG.

Conclusion: This study has shown similar survival outcomes between PG and TG for patients with T2-3 EGJ-UG adenocarcinoma and with tumor size <4 cm.

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T2-3食管胃交界腺癌和上三分胃腺癌患者近端胃切除术与全胃切除术的长期生存结局：倾向评分匹配分析

背景：我们的目的是研究局部晚期食管胃交界处腺癌和上三分之一胃腺癌（EGJ-UG腺癌）患者接受近端胃切除术（PG）或全胃切除术（TG）的长期生存结果。方法：我们从监测、流行病学和最终结果（SEER）数据库中检索和分析数据。T2-3 EGJ-UG腺癌患者接受TG或PG治疗。我们进行了倾向评分1:2匹配，并生成匹配的数据集并进行比较。我们根据手术入路的分层获得了患者的长期生存效益。结果：从SEER数据库中确定的1291例患者中，901例（69.8%）患者接受PG治疗，390例（30.2%）患者接受TG治疗。配对后，PG组584例患者与TG组344例患者进行倾向评分匹配。在不同手术入路的匹配数据中，总生存率和癌症特异性生存率没有差异。对于肿瘤大小≤4 cm的患者，接受PG和TG的患者的长期生存率相似。对于肿瘤大小为b> - 4cm的患者，与PG相比，TG与总生存期和肿瘤特异性生存期相关。结论：本研究显示PG和TG在T2-3 EGJ-UG腺癌患者和肿瘤大小相似的生存结果

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来源期刊

Gastroenterology Report Medicine-Gastroenterology

CiteScore

4.60

自引率

2.80%

发文量

审稿时长

8 weeks

期刊介绍： Gastroenterology Report is an international fully open access (OA) online only journal, covering all areas related to gastrointestinal sciences, including studies of the alimentary tract, liver, biliary, pancreas, enteral nutrition and related fields. The journal aims to publish high quality research articles on both basic and clinical gastroenterology, authoritative reviews that bring together new advances in the field, as well as commentaries and highlight pieces that provide expert analysis of topical issues.