Hematological analysis of alpha-thalassemia: A single-center, retrospective clinical study.

IF 2.6 3区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

PLoS ONE Pub Date : 2025-08-04 eCollection Date: 2025-01-01 DOI:10.1371/journal.pone.0329365

Lin Zheng, Nuolan Yin, Meiying Wang, Hailong Huang, Na Lin, Shuyu Zhang, Linjuan Su, Liangpu Xu

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引用次数: 0

Abstract

Objectives: To determine the optimal cutoffs of the three indicators (MCV, MCH and HbA2) for alpha-thalassemia screening and to evaluate the validity of these indicators in Fujian Province, China.

Methods: We conducted a retrospective analysis on the results of specimens received from May 2016 to April 2023. Receiver operating characteristic (ROC) curves were used to confirm the optimal cutoffs of the screening indicators. And the effectiveness of different combined screening methods was evaluated in patients with and without alpha-thalassemia.

Results: The optimal cutoffs of MCV, MCH, and HbA2 were 77.85, 27.05 and 2.55, respectively. Among them, the area under the ROC curve of MCH was 0.912, and it was the best of the three parameters used for alpha-thalassemia screening.

Conclusions: The results can help clinicians and laboratory technicians perform genetic counseling and prenatal diagnosis for patients. It also provide a reference for alpha-thalassemia genotype distributions in our region and the optimal cutoff values of MCV, MCH and HbA2.

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地中海贫血的血液学分析：一项单中心回顾性临床研究。

目的：确定MCV、MCH和HbA2 3项指标筛查α -地中海贫血的最佳截止点，并评价这些指标在福建省的有效性。方法：对2016年5月至2023年4月收集的标本结果进行回顾性分析。采用受试者工作特征（ROC）曲线确定筛选指标的最佳截止点。并评价了不同联合筛查方法在患有和不患有-地中海贫血患者中的有效性。结果：MCV、MCH和HbA2的最佳临界值分别为77.85、27.05和2.55。其中，MCH的ROC曲线下面积为0.912，是3个筛选α -地中海贫血的参数中效果最好的。结论：该结果可帮助临床医生和实验室技术人员对患者进行遗传咨询和产前诊断。为本地区α -地中海贫血基因型分布及MCV、MCH和HbA2的最佳临界值提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

PLoS ONE 生物-生物学

CiteScore

6.20

自引率

5.40%

发文量

14242

审稿时长

3.7 months

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