Cancer-specific Regulation of Metabolic and Epigenetic Pathways by Dietary Phytochemicals.

IF 4.3 3区医学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Pharmaceutical Research Pub Date : 2025-08-01 Epub Date: 2025-08-04 DOI:10.1007/s11095-025-03898-0

Yuxin Pan, Rebecca Mary Peter, Pochung Chou, Parv Dushyant Dave, Jiawei Xu, Ahmad Shanner, Md Shahid Sarwar, Ah-Ng Kong

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Abstract

Background: Cancer is a complex disease triggered by a combination of genetic mutations, metabolic reprogramming, epigenetic modifications, and environmental factors, and is one of the leading health burdens worldwide. Dietary phytochemical are effective in reducing the incidence of cancer by regulating epigenetic and metabolic pathways and possess great potential in cancer prevention and treatment.

Objectives: This review aims to summarize the relevant metabolic and epigenetic changes in cancer, recent research progress in the mechanism study of dietary phytochemicals by regulating key pathways and provides new insights for further research.

Methods: We searched the relevant literature by searching through common databases, such as PubMed, Medline, ScienceDirect, Google Scholar and Web of Science, and summarized the anticancer effects of potential dietary phytochemicals regulating epigenetic and metabolic pathways in common cancers, such as colorectal cancer, prostate cancer, lung cancer, skin cancer, and breast cancer.

Results: Natural phytochemicals not only regulate key pathways, such as DNA methylation, histone modifications, oxidative stress, inflammation, and metabolic reprogramming, but also demonstrate multi-targeted intervention in tumor therapy by inducing apoptosis, inhibiting cell proliferation, angiogenesis, and metastasis. Additionally, the potential of dietary phytochemicals to reverse metabolic and epigenetic changes makes them promising as adjunctive or alternative therapies.

Conclusion: Phytochemicals exhibit significant effects in cancer prevention and treatment by targeting metabolic and epigenetic regulatory networks. Future research should further explore their mechanisms, clinical translational value, and synergistic effects with traditional therapies to provide theoretical foundations and practical guidance for developing new cancer intervention strategies.

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膳食植物化学物质对癌症特异性代谢和表观遗传途径的调节。

背景：癌症是一种由基因突变、代谢重编程、表观遗传修饰和环境因素共同引发的复杂疾病，是全球主要的健康负担之一。膳食植物化学物质通过调节表观遗传和代谢途径，有效降低癌症发病率，在癌症防治方面具有巨大潜力。目的：本文综述了癌症中相关代谢和表观遗传学变化，以及膳食植物化学物质通过调控关键通路的机制研究的最新进展，为进一步研究提供新的思路。方法：通过PubMed、Medline、ScienceDirect、b谷歌Scholar和Web of Science等常用数据库检索相关文献，总结膳食植物化学物质调节结肠癌、前列腺癌、肺癌、皮肤癌和乳腺癌等常见癌症的表观遗传和代谢途径的抗癌作用。结果：天然植物化学物质不仅调控DNA甲基化、组蛋白修饰、氧化应激、炎症和代谢重编程等关键通路，还通过诱导细胞凋亡、抑制细胞增殖、血管生成和转移等多种途径参与肿瘤治疗。此外，膳食植物化学物质具有逆转代谢和表观遗传变化的潜力，这使得它们有望成为辅助或替代疗法。结论：植物化学物质通过靶向代谢和表观遗传调控网络在癌症防治中发挥重要作用。未来的研究应进一步探讨其作用机制、临床转化价值以及与传统疗法的协同效应，为制定新的癌症干预策略提供理论基础和实践指导。

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来源期刊

Pharmaceutical Research 医学-化学综合

CiteScore

6.60

自引率

5.40%

发文量

276

审稿时长

3.4 months

期刊介绍： Pharmaceutical Research, an official journal of the American Association of Pharmaceutical Scientists, is committed to publishing novel research that is mechanism-based, hypothesis-driven and addresses significant issues in drug discovery, development and regulation. Current areas of interest include, but are not limited to: -(pre)formulation engineering and processing- computational biopharmaceutics- drug delivery and targeting- molecular biopharmaceutics and drug disposition (including cellular and molecular pharmacology)- pharmacokinetics, pharmacodynamics and pharmacogenetics. Research may involve nonclinical and clinical studies, and utilize both in vitro and in vivo approaches. Studies on small drug molecules, pharmaceutical solid materials (including biomaterials, polymers and nanoparticles) biotechnology products (including genes, peptides, proteins and vaccines), and genetically engineered cells are welcome.