Perinatal growth and neurodevelopmental outcomes in preterm infants conceived via assisted reproductive technology: a retrospective comparative cohort study.
Shan He, Jian-Hua Yu, Xiao-Zhi Xu, Heng Zhang, Fei Wang, Ou Jiang, Hong-Ying Mi
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引用次数: 0
Abstract
Objective: This study aims to compare growth parameters and neurodevelopment outcomes between preterm infants conceived via assisted reproductive technology (ART) and those conceived spontaneously, with a focus on head circumference, length, weight, and developmental performance as assessed by the Gesell Developmental Scales.
Methods: Propensity score matching was employed to balance baseline characteristics between groups. Post-matching comparisons were conducted for head circumference, length, and weight at birth, 1 month, and 3 months of age. Neurodevelopmental assessments were performed at 1, 2, and 3 years using the Gesell scales. After PSM, a total of 290 preterm infants were included in the final analysis, with 145 infants in each of the ART and non-ART groups, respectively.
Results: Following matching, baseline characteristics were comparable between the groups. At both 1 month and 3 months of age, ART-conceived infants group demonstrated significantly lower mean head circumference, length, and weight compared to infants conceived spontaneously. Additionally, ART-conceived infants demonstrated significantly lower developmental scores at 1 and 2 years of age (p < 0.05).
Conclusions: Preterm infants conceived via ART exhibited comparatively lower growth metrics developmental scores during early infancy compared to their spontaneously conceived counterparts. These findings highlight the importance for proactive clinical monitoring and targeted early interventions to support optimal outcomes in this population.
期刊介绍：
The Journal of Assisted Reproduction and Genetics publishes cellular, molecular, genetic, and epigenetic discoveries advancing our understanding of the biology and underlying mechanisms from gametogenesis to offspring health. Special emphasis is placed on the practice and evolution of assisted reproduction technologies (ARTs) with reference to the diagnosis and management of diseases affecting fertility. Our goal is to educate our readership in the translation of basic and clinical discoveries made from human or relevant animal models to the safe and efficacious practice of human ARTs. The scientific rigor and ethical standards embraced by the JARG editorial team ensures a broad international base of expertise guiding the marriage of contemporary clinical research paradigms with basic science discovery. JARG publishes original papers, minireviews, case reports, and opinion pieces often combined into special topic issues that will educate clinicians and scientists with interests in the mechanisms of human development that bear on the treatment of infertility and emerging innovations in human ARTs. The guiding principles of male and female reproductive health impacting pre- and post-conceptional viability and developmental potential are emphasized within the purview of human reproductive health in current and future generations of our species.
The journal is published in cooperation with the American Society for Reproductive Medicine, an organization of more than 8,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.
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