Whole recombinant yeast-based vaccines: concept, importance, issues, and future scope.

IF 7.7 2区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Critical Reviews in Biotechnology Pub Date : 2025-08-04 DOI:10.1080/07388551.2025.2536808

Ravinder Kumar, Vartika Srivastava, Aijaz Ahmad, Santi M Mandal, Piyush Baindara

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引用次数: 0

Abstract

Despite their tremendous benefits to society, currently licensed vaccines, including mRNA-based ones, are far from ideal and suffer several issues. Common problems associated with all types of vaccine formulations currently in clinical use include thermolabile nature, poor shelf life at ambient temperature, and the continuous need for cold chain and sometimes ultra-low temperature. Several approaches have been tested in the past to surmount these shortcomings. This review discusses the advantages of whole yeast (WY) or whole recombinant yeast-based (WRY) vaccines compared to other vaccine formulations to overcome the above-mentioned issues. The interaction between yeast cells and the host immune system in relevance to the WRY vaccines has been discussed along with the importance of whole yeast cells in the development of anti-fungal vaccines by highlighting the bottlenecks hampering the use of WRY in vaccine formulation. Specifically, the present review highlighted the status of WRY vaccines, including those in clinical trials, and also summarized the guidelines, one should follow while conducting research or reporting the data related to WRY vaccines.

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全重组酵母疫苗：概念、重要性、问题和未来范围。

尽管它们给社会带来了巨大的好处，但目前获得许可的疫苗，包括基于mrna的疫苗，远非理想，并存在几个问题。目前临床使用的所有类型疫苗制剂的共同问题包括耐热性、环境温度下的保质期差、持续需要冷链，有时需要超低温。过去已经测试了几种方法来克服这些缺点。本文综述了全酵母（WY）或全重组酵母（WRY）疫苗与其他疫苗制剂相比的优势，以克服上述问题。酵母细胞与宿主免疫系统之间的相互作用与抗真菌疫苗的相关性，以及整个酵母细胞在抗真菌疫苗开发中的重要性，通过强调阻碍在疫苗配方中使用抗真菌疫苗的瓶颈进行了讨论。具体而言，本综述强调了包括临床试验在内的反转录疫苗的现状，并总结了在进行反转录疫苗研究或报告与反转录疫苗有关的数据时应遵循的准则。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Reviews in Biotechnology 工程技术-生物工程与应用微生物

CiteScore

20.80

自引率

1.10%

发文量

审稿时长

4.8 months

期刊介绍： Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.