Update in Inflammatory Bowel Disease Management in the Elderly.

Q1 Medicine

Current Gastroenterology Reports Pub Date : 2025-08-04 DOI:10.1007/s11894-025-01005-2

Farhad Peerani

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引用次数: 0

Abstract

Purpose of review: This review article aims to summarize the safety and efficacy of medical therapies in elderly inflammatory bowel disease (IBD) patients contextualizing the therapies within the framework of polypharmacy, comorbidities and frailty.

Recent findings: Anti-TNF therapies are the most extensively studied advanced therapy in elderly IBD patients. Based on most published studies, elderly IBD patients on anti-TNF therapy versus no advanced therapy demonstrate decreased treatment persistence that could be attributed to both diminished clinical response and increased adverse events. Caution should be used when considering Janus Kinase inhibitors in the elderly given the risk of infection and the possible increased risk of thrombosis. The majority of literature on the medical management of elderly IBD patients revolves around retrospective and observational studies. Further prospective research is required in the areas of disease pathophysiology, comparative effectiveness of therapies and frailty to better inform clinical practice. Multidisciplinary care models can best position elderly IBD patients to obtain optimal outcomes.

查看原文本刊更多论文

老年炎症性肠病管理的最新进展。

综述目的：本文旨在总结在多种药物、合并症和虚弱的框架下，老年炎症性肠病（IBD）患者的药物治疗的安全性和有效性。最近发现：抗肿瘤坏死因子治疗是老年IBD患者研究最广泛的高级治疗方法。根据大多数已发表的研究，接受抗tnf治疗的老年IBD患者与未接受高级治疗的患者相比，治疗持久性较低，这可能归因于临床反应减弱和不良事件增加。考虑到感染风险和可能增加的血栓形成风险，在老年人中使用Janus激酶抑制剂时应谨慎。大多数关于老年IBD患者医疗管理的文献都是回顾性和观察性研究。进一步的前瞻性研究需要在疾病病理生理学、治疗的比较有效性和虚弱等领域更好地为临床实践提供信息。多学科护理模式可以对老年IBD患者进行最佳定位，以获得最佳治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Gastroenterology Reports Medicine-Gastroenterology

CiteScore

7.80

自引率

0.00%

发文量

期刊介绍： As the field of gastroenterology and hepatology rapidly evolves, the wealth of published literature can be overwhelming. The aim of the journal is to help readers stay abreast of such advances by offering authoritative, systematic reviews by leading experts. We accomplish this aim by appointing Section Editors who invite international experts to contribute review articles that highlight recent developments and important papers published in the past year. Major topics in gastroenterology are covered, including pediatric gastroenterology, neuromuscular disorders, infections, nutrition, and inflammatory bowel disease. These reviews provide clear, insightful summaries of expert perspectives relevant to clinical practice. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. We also provide commentaries from well-known figures in the field.