Histoplasma capsulatum Not Detected in People with HIV and Systemic Symptoms in Port-au-Prince, Haiti.

IF 1.1 4区医学 Q4 IMMUNOLOGY

AIDS research and human retroviruses Pub Date : 2025-08-18 DOI:10.1177/08892229251365925

Kathryn M Dupnik, Nancy Dorvil, Maureen Ward, Vanessa Rivera, Alexandra Apollon, Emelyne Dumont, Omar Sued, Jean W Pape, Serena P Koenig

引用次数: 0

Abstract

When local epidemiology of endemic fungal infections is poorly understood, it is difficult to determine the clinical impact of screening for these pathogens in people living with HIV. We found no Histoplasma urine antigen or serum antibody in over 450 symptomatic patients with a new diagnosis of HIV in Port-au-Prince, Haiti. These findings indicate that systematic testing is likely to be low yield in Port-au-Prince, although it is well described in other countries in the region, and may have higher prevalence in rural areas. These findings are relevant to other settings where the prevalence of histoplasmosis is poorly defined, as similar studies could also inform local evidence-based guidelines.

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在海地太子港的艾滋病毒感染者和全身症状中未检测到荚膜组织浆体。

当对地方性真菌感染的当地流行病学知之甚少时，很难确定在艾滋病毒感染者中筛查这些病原体的临床影响。我们在海地太子港450多名新诊断为艾滋病毒的有症状患者中未发现尿组织浆体抗原或血清抗体。这些发现表明，太子港的系统测试可能是低产量的，尽管在该区域的其他国家有很好的描述，并且在农村地区可能有更高的流行率。这些发现与组织胞浆菌病患病率不明确的其他环境相关，因为类似的研究也可以为当地的循证指南提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

AIDS research and human retroviruses 医学-病毒学

CiteScore

3.10

自引率

6.70%

发文量

201

审稿时长

3-6 weeks

期刊介绍： AIDS Research and Human Retroviruses was the very first AIDS publication in the field over 30 years ago, and today it is still the critical resource advancing research in retroviruses, including AIDS. The Journal provides the broadest coverage from molecular biology to clinical studies and outcomes research, focusing on developments in prevention science, novel therapeutics, and immune-restorative approaches. Cutting-edge papers on the latest progress and research advances through clinical trials and examination of targeted antiretroviral agents lead to improvements in translational medicine for optimal treatment outcomes. AIDS Research and Human Retroviruses coverage includes: HIV cure research HIV prevention science - Vaccine research - Systemic and Topical PreP Molecular and cell biology of HIV and SIV Developments in HIV pathogenesis and comorbidities Molecular biology, immunology, and epidemiology of HTLV Pharmacology of HIV therapy Social and behavioral science Rapid publication of emerging sequence information.