Health risk associated with exposure to atrazine residue in drinking water, soil and cassava (Manihot esculenta) from seven hard-to-reach farm settlements in Ago-Iwoye, Southwest Nigeria

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology Pub Date : 2025-08-05 DOI:10.1016/j.fct.2025.115684

Folarin Owagboriaye , Olusolape Ilusanya , Abdulwahab Osibogun , Ebenezer Dada , Marvelous Ariyibi , Opeyemi Ogunbiyi , Titilayo Adesetan , Gabriel Dedeke

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Abstract

Studies on health risks associated with exposure to atrazine have largely focused on a single exposure pathway, less attention has been given to its potential integral risks resulting from multiple exposures. This study evaluated health risks associated with exposure to atrazine residues in drinking water, soil and cassava from seven hard-to-reach farm settlements in Ago-Iwoye, Nigeria. Drinking water, soils and cassava tuber collected from each farm settlement were analysed for atrazine residues using standard technique. The mean values obtained were used to evaluate exposure-related carcinogenic and non-carcinogenic health risks. Atrazine in soil ranged from 0.19 to 0.380 mg/kg. While a range of 0.01–0.04 mg/L was detected in stream water, cassava recorded a range of 0.004–0.008 mg/kg. Hazard Index associated with water and soil exposure was below the risk limit. Although the incremental lifetime cancer risk (ILCR) associated with soil was below the threshold risk limit, the ILCR associated with water exposure was slightly above the limit. The EDI and HRI associated with cassava consumption were below the threshold values for adults, but not for children. Exposure to water or cassava, but not soil, from the farm settlements may pose high risks, especially to children.

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与接触来自尼日利亚西南部阿戈-伊沃伊七个难以到达的农场居民点的饮用水、土壤和木薯（Manihot esculenta）中的阿特拉津残留有关的健康风险。

与阿特拉津接触有关的健康风险研究主要集中在单一接触途径上，对多次接触可能造成的整体风险的关注较少。本研究评估了与接触尼日利亚Ago-Iwoye七个难以到达的农场居民点的饮用水、土壤和木薯中的阿特拉津残留物相关的健康风险。使用标准技术对从每个农场收集的饮用水、土壤和木薯块茎进行了阿特拉津残留分析。获得的平均值用于评估与暴露相关的致癌性和非致癌性健康风险。土壤中阿特拉津含量为0.19 ~ 0.380 mg/kg。虽然在溪水中检测到的范围为0.01至0.04毫克/升，但木薯的记录范围为0.004至0.008毫克/公斤。与水和土壤暴露相关的危害指数低于风险限值。虽然与土壤相关的终生癌症增量风险（ILCR）低于阈值风险限制，但与水接触相关的ILCR略高于阈值风险限制。与食用木薯相关的EDI和HRI在成人中低于阈值，但在儿童中没有。接触来自农场定居点的水或木薯（而不是土壤）可能构成高风险，尤其是对儿童。

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来源期刊

Food and Chemical Toxicology 工程技术-毒理学

CiteScore

10.90

自引率

4.70%

发文量

651

审稿时长

31 days

期刊介绍： Food and Chemical Toxicology (FCT), an internationally renowned journal, that publishes original research articles and reviews on toxic effects, in animals and humans, of natural or synthetic chemicals occurring in the human environment with particular emphasis on food, drugs, and chemicals, including agricultural and industrial safety, and consumer product safety. Areas such as safety evaluation of novel foods and ingredients, biotechnologically-derived products, and nanomaterials are included in the scope of the journal. FCT also encourages submission of papers on inter-relationships between nutrition and toxicology and on in vitro techniques, particularly those fostering the 3 Rs. The principal aim of the journal is to publish high impact, scholarly work and to serve as a multidisciplinary forum for research in toxicology. Papers submitted will be judged on the basis of scientific originality and contribution to the field, quality and subject matter. Studies should address at least one of the following: -Adverse physiological/biochemical, or pathological changes induced by specific defined substances -New techniques for assessing potential toxicity, including molecular biology -Mechanisms underlying toxic phenomena -Toxicological examinations of specific chemicals or consumer products, both those showing adverse effects and those demonstrating safety, that meet current standards of scientific acceptability. Authors must clearly and briefly identify what novel toxic effect (s) or toxic mechanism (s) of the chemical are being reported and what their significance is in the abstract. Furthermore, sufficient doses should be included in order to provide information on NOAEL/LOAEL values.