Combined Toxicity of Heavy Metal Cadmium and Insecticide Chlorpyrifos to Drosophila S2 Cells.

IF 2.2 4区 环境科学与生态学 Q3 ENVIRONMENTAL SCIENCES
Yi-Jun Wu, Kelai Kang, Wenyao Yang, Quangen Wu, Rui Chen, Xingfan Zhou
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引用次数: 0

Abstract

Cadmium (Cd) is a heavy metal, and chlorpyrifos (CPF) is a widely used organophosphorus insecticide, which are widespread environmental pollutants. These two chemicals can induce the production of reactive oxygen species (ROS) in mammals and cause oxidative damage. However, the mechanism of their combined toxicity in invertebrates and especially insects has not been well documented. In this study, we investigated the combined toxicity of Cd and CPF by using Drosophila S2 cell as a test model. We found that cell viability and antioxidant enzyme activities were reduced and the lipids and proteins peroxidation as well as ROS were induced after the treatment. Cd and CPF displayed an antagonistic interaction in the induction of oxidative damage and the reduction of cell viability. The results indicated that Cd and CPF interfere with the toxicity of each other in the cells, which implies that Cd could influence the effect of CPF used for pest insects control.

重金属镉和杀虫剂毒死蜱对果蝇S2细胞的联合毒性研究。
镉(Cd)是一种重金属,毒死蜱(CPF)是一种广泛使用的有机磷杀虫剂,是广泛存在的环境污染物。这两种化学物质可以诱导哺乳动物产生活性氧(ROS)并引起氧化损伤。然而,它们对无脊椎动物特别是昆虫的联合毒性机制尚未得到很好的记载。本研究以果蝇S2细胞为实验模型,研究了Cd和CPF的联合毒性。我们发现,处理后细胞活力和抗氧化酶活性降低,脂质和蛋白质过氧化以及ROS诱导。Cd和CPF在诱导氧化损伤和降低细胞活力方面表现出拮抗作用。结果表明,Cd和CPF在细胞内相互干扰,提示Cd可能会影响CPF防治害虫的效果。
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来源期刊
CiteScore
5.60
自引率
3.70%
发文量
230
审稿时长
1.7 months
期刊介绍: The Bulletin of Environmental Contamination and Toxicology(BECT) is a peer-reviewed journal that offers rapid review and publication. Accepted submissions will be presented as clear, concise reports of current research for a readership concerned with environmental contamination and toxicology. Scientific quality and clarity are paramount.
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