Thiourea and squaramide organocatalysts for the asymmetric total synthesis of natural compounds

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-08-05 DOI:10.1039/d5ob00800j

Márcia Rénio , M. Rita Ventura

引用次数: 0

Abstract

Thiourea and squaramide organocatalysts have become essential tools in asymmetric synthesis, offering metal-free, highly selective methods for the efficient synthesis of complex natural products with important biological activities. Through directional hydrogen bonding, these catalysts activate electrophilic substrates with remarkable stereocontrol. This short review highlights recent advances demonstrating the power of these catalysts in the enantioselective synthesis of intricate natural scaffolds.

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天然化合物不对称全合成的硫脲和方酰胺有机催化剂。

硫脲和方酰胺有机催化剂已成为不对称合成的重要工具，为高效合成具有重要生物活性的复杂天然产物提供了无金属、高选择性的方法。这些催化剂通过定向氢键活化亲电底物，具有显著的立体控制作用。这篇简短的综述强调了这些催化剂在复杂的天然支架的对映选择性合成中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.