A visible-light-promoted perfluoroalkylation/cyclization cascade towards perfluoroalkyl-substituted iminoisobenzofurans using the EDA complex

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-08-05 DOI:10.1039/d5ob00888c

Zilin Liu , Shuo Gao , Mingxi Hu , Zhen-Hua Zhang , Pifeng Wei , Mengmeng Zhao

引用次数: 0

Abstract

Perfluoroalkyl-functionalized heterocycles exhibit profoundly modified bioactivities, motivating the development of efficient methods for precise perfluoroalkyl group installation. A new metal-free photoinduced radical-initiated cascade reaction was developed for the rapid synthesis of perfluoroalkyl-substituted iminoisobenzofurans by reacting various perfluoroalkyl iodides (R_F-I) under mild reaction conditions. In this reaction system, the formation of electron donor–acceptor (EDA) complexes is pivotal for the visible-light promoted transformation in the absence of additional photocatalytic species.

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利用EDA配合物对全氟烷基取代亚氨基异苯并呋喃进行可见光促进的全氟烷基化/环化级联反应。

全氟烷基功能化杂环表现出深刻的生物活性，促进了全氟烷基精确安装的有效方法的发展。在温和的反应条件下，以不同的全氟烷基碘化物（RF-I）为原料，建立了一种新的无金属光诱导自由基引发级联反应，用于快速合成全氟烷基取代亚氨基异苯并呋喃。在该反应体系中，电子给体-受体（EDA）复合物的形成是在没有其他光催化物质的情况下可见光促进转化的关键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.