Characteristics of Adults With Non-Hospitalized Severe Respiratory Illness: Findings From a COVID-19 Vaccine Effectiveness Evaluation in Kenya, 2022–2023

IF 4.2 4区医学 Q1 INFECTIOUS DISEASES

Influenza and Other Respiratory Viruses Pub Date : 2025-08-06 DOI:10.1111/irv.70145

Radhika Gharpure, Young M. Yoo, Bryan O. Nyawanda, Raphael O. Anyango, Brian O. Onyando, Sidney Ogolla, Billy Ogwel, Eric Osoro, Philip Ngere, Samuel Kadivane, Nzisa Liku, Eva Leidman, Gideon O. Emukule, Richard Omore, Kathryn E. Lafond

{"title":"Characteristics of Adults With Non-Hospitalized Severe Respiratory Illness: Findings From a COVID-19 Vaccine Effectiveness Evaluation in Kenya, 2022–2023","authors":"Radhika Gharpure, Young M. Yoo, Bryan O. Nyawanda, Raphael O. Anyango, Brian O. Onyando, Sidney Ogolla, Billy Ogwel, Eric Osoro, Philip Ngere, Samuel Kadivane, Nzisa Liku, Eva Leidman, Gideon O. Emukule, Richard Omore, Kathryn E. Lafond","doi":"10.1111/irv.70145","DOIUrl":null,"url":null,"abstract":"<p>Studies suggest the burden of non-hospitalized severe respiratory illness might be substantial in Kenya. Using data from a Kenya COVID-19 vaccine effectiveness evaluation, we compared characteristics of patients aged ≥12 years who were hospitalized with severe respiratory illness to outpatients who were referred for hospitalization and declined (non-hospitalized). Symptom presentation and lung radiograph findings were similar among both groups, and patients in both were diagnosed with critical conditions, including acute respiratory distress syndrome (12% hospitalized; 4% non-hospitalized) and sepsis (10% both). Findings underscore the importance of including non-hospitalized severe illness when estimating the burden of disease for respiratory viruses.</p>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":"19 8","pages":""},"PeriodicalIF":4.2000,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.70145","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Influenza and Other Respiratory Viruses","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/irv.70145","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Studies suggest the burden of non-hospitalized severe respiratory illness might be substantial in Kenya. Using data from a Kenya COVID-19 vaccine effectiveness evaluation, we compared characteristics of patients aged ≥12 years who were hospitalized with severe respiratory illness to outpatients who were referred for hospitalization and declined (non-hospitalized). Symptom presentation and lung radiograph findings were similar among both groups, and patients in both were diagnosed with critical conditions, including acute respiratory distress syndrome (12% hospitalized; 4% non-hospitalized) and sepsis (10% both). Findings underscore the importance of including non-hospitalized severe illness when estimating the burden of disease for respiratory viruses.

Abstract Image

查看原文本刊更多论文

非住院严重呼吸系统疾病成人的特征：2022-2023年肯尼亚COVID-19疫苗有效性评估结果

研究表明，在肯尼亚，非住院严重呼吸系统疾病的负担可能很大。使用来自肯尼亚COVID-19疫苗有效性评估的数据，我们比较了年龄≥12岁因严重呼吸系统疾病住院的患者与转诊住院并拒绝住院（非住院）的门诊患者的特征。两组患者的症状表现和肺部x线检查结果相似，两组患者均被诊断为危重情况，包括急性呼吸窘迫综合征(12%住院；4%未住院)和败血症（两者均为10%）。研究结果强调了在估计呼吸道病毒疾病负担时包括非住院严重疾病的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Influenza and Other Respiratory Viruses 医学-病毒学

CiteScore

7.20

自引率

4.50%

发文量

120

审稿时长

6-12 weeks

期刊介绍： Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases. Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.