Dose Performing Multiple Biopsy Strokes From the Same Site Improve Specimen Adequacy in Cholangioscopy-Guided Mapping Biopsy for Extrahepatic Cholangiocarcinoma?

IF 1.5 Q3 GASTROENTEROLOGY & HEPATOLOGY

JGH Open Pub Date : 2025-08-06 DOI:10.1002/jgh3.70246

Takahisa Ogawa, Yoshihide Kanno, Shinsuke Koshita, Hiroaki Kusunose, Toshitaka Sakai, Keisuke Yonamine, Kazuaki Miyamoto, Fumisato Kozakai, Haruka Okano, Kento Hosokawa, Hidehito Sumiya, Yutaka Noda, Kei Ito

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Abstract

Objectives

Cholangioscopy-guided mapping biopsy (CMB) is performed for preoperative evaluation of extrahepatic cholangiocarcinoma. The aim of this study was to evaluate the usefulness of CMB using a SpyBite Max and to determine the effectiveness of multiple biopsy strokes from the same site.

Methods

Between August 2020 and October 2022, 21 patients with extrahepatic cholangiocarcinoma were enrolled in this prospective observational study. The primary outcome was the rate of site-based successful biopsies, which was defined as the acquisition of epithelium-containing material appropriate for diagnosing benignity/malignancy from each site. The cumulative success rate of obtaining appropriate materials increased by increasing biopsy strokes from 1 to 4.

Results

The cholangioscope could be advanced to all 80 target sites. The overall adequate specimen rate was 67% (142/212). The overall rate of site-based successful biopsies was 83% (66/80). The cumulative success rate of obtaining appropriate materials did not significantly improve by increasing the number of biopsy strokes from 1 (81%) to 4 (86%).

Conclusions

The biopsy material was obtained for 83% of the required sites. However, repetitive biopsy strokes for the same site did not improve the rate of site-based successful biopsy. This study was registered in UMIN (UMIN000041530).

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在胆管镜引导下肝外胆管癌的穿刺活检中，在同一部位进行多次活检是否能提高标本的充分性？

目的对肝外胆管癌的术前诊断进行胆管镜引导下的定位活检（CMB）。本研究的目的是利用SpyBite Max评估CMB的有效性，并确定来自同一部位的多次活检卒中的有效性。方法在2020年8月至2022年10月期间，21例肝外胆管癌患者被纳入这项前瞻性观察研究。主要结果是基于部位的成功活检率，其定义为从每个部位获得适合诊断良性/恶性的含上皮物质。通过将活检卒中数从1增加到4，获得合适材料的累积成功率增加。结果胆道镜可提前到80个靶部位。总体充足标本率为67%（142/212）。现场活检成功率为83%（66/80）。将活检卒中次数从1次（81%）增加到4次（86%），获得合适材料的累积成功率并没有显著提高。结论：83%的活检部位获得了活检材料。然而，同一部位的重复活检卒中并没有提高基于部位的活检成功率。本研究已在UMIN注册（UMIN000041530）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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