Factors influencing stifle stability in canine limb press models: A systematic review and meta-analysis

IF 1.8 3区农林科学 Q1 VETERINARY SCIENCES

Research in veterinary science Pub Date : 2025-08-05 DOI:10.1016/j.rvsc.2025.105826

Glauco Vinício Chaves , Kathrine Højte Dahl , Michelle Brønniche Møller Nielsen , Leonardo Augusto Lopes Muzzi , James Edward Miles

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引用次数: 0

Abstract

Limb press models have been widely used to explore aspects of canine stifle stability and to inform surgical practice. This systematic review aimed to synthesize test conditions, periarticular forces, and stability measures in canine limb press models for comparison with in vivo measurements. Six databases (EMBASE, Ovid MEDLINE, CAB abstracts, Agricola, Scopus, and Web of Science) were searched from inception to 17.03.2025. Peer-reviewed experimental studies using static, axially loaded, whole-limb constructs and reporting cranial tibial translation, rotation, and/or periarticular forces were eligible for inclusion. Twenty-three articles were included, reporting results from 368 healthy limbs of dogs of various breeds. Most (17/23) simulated stance during walking but landmarks for limb angulation were frequently poorly described or deviated from those used in cited studies. Cranial cruciate ligament transection caused mean cranial translation of 14.6 mm and mean internal rotation of 13.1°. Cranial translation and rotation were improved by osteotomy techniques, but data were heterogeneous, sample sizes were often small, and reporting standards inconsistent. Key data regarding quadriceps, gastrocnemius, or cranial thrust forces were extremely limited. This review identified potentially serious knowledge gaps regarding simulated muscle and periarticular forces, and concerns over limb angulation. Further evaluation of ex vivo models is warranted to determine the likely validity of currently reported models. If current models are shown to simulate muscle forces which do not reflect expected in vivo loading, this could help explain the difference between in vivo and ex vivo assessments of joint stability following surgeries such as TPLO and TTA.

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影响犬肢压迫模型膝关节稳定性的因素：系统回顾和荟萃分析

肢体按压模型已被广泛应用于探索犬膝关节稳定性的各个方面，并为外科实践提供信息。本系统综述的目的是综合测试条件，关节周围的力量，并在犬肢体按压模型的稳定性措施与体内测量进行比较。检索了六个数据库（EMBASE、Ovid MEDLINE、CAB abstracts、Agricola、Scopus和Web of Science），检索时间从成立到2025年3月17日。同行评议的实验研究采用静态、轴向加载、全肢结构，并报告颅胫骨平移、旋转和/或关节周围力，符合纳入条件。纳入了23篇文章，报告了不同品种的368只健康犬肢的结果。大多数（17/23）模拟了行走时的姿势，但肢体成角的标志经常描述不佳或偏离引用研究中使用的标志。颅十字韧带横断导致平均颅平移14.6 mm，平均内旋13.1°。截骨技术改善了颅骨的平移和旋转，但数据不均匀，样本量通常较小，报告标准不一致。关于股四头肌、腓肠肌或颅骨推力的关键数据极为有限。这篇综述发现了关于模拟肌肉和关节周围力的潜在严重知识缺口，以及对肢体成角的关注。有必要对离体模型进行进一步评估，以确定目前报道的模型的可能有效性。如果目前的模型被证明模拟的肌肉力量并不反映预期的体内负荷，这将有助于解释TPLO和TTA等手术后关节稳定性的体内和体外评估之间的差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Research in veterinary science 农林科学-兽医学

CiteScore

4.40

自引率

4.20%

发文量

312

审稿时长

75 days

期刊介绍： Research in Veterinary Science is an International multi-disciplinary journal publishing original articles, reviews and short communications of a high scientific and ethical standard in all aspects of veterinary and biomedical research. The primary aim of the journal is to inform veterinary and biomedical scientists of significant advances in veterinary and related research through prompt publication and dissemination. Secondly, the journal aims to provide a general multi-disciplinary forum for discussion and debate of news and issues concerning veterinary science. Thirdly, to promote the dissemination of knowledge to a broader range of professions, globally. High quality papers on all species of animals are considered, particularly those considered to be of high scientific importance and originality, and with interdisciplinary interest. The journal encourages papers providing results that have clear implications for understanding disease pathogenesis and for the development of control measures or treatments, as well as those dealing with a comparative biomedical approach, which represents a substantial improvement to animal and human health. Studies without a robust scientific hypothesis or that are preliminary, or of weak originality, as well as negative results, are not appropriate for the journal. Furthermore, observational approaches, case studies or field reports lacking an advancement in general knowledge do not fall within the scope of the journal.