{"title":"Advanced 3D printing and multiscale technologies (nano to macro) for personalized biomedical applications","authors":"Saranya Balasubramaniyam, Thirumalaikumaran Rathinam, Mohanakrishnan Srinivasan, Karthikeyan Elumalai","doi":"10.1016/j.bprint.2025.e00430","DOIUrl":null,"url":null,"abstract":"<div><div>The combination of 3D printing and nanotechnology is remodeling the field of biomedical innovation, opening up unprecedented levels of precision, personalization, and function in health care. 3D printing provides the capacity to print complex, patient-specific constructs, and nanotechnology extends this with dynamic biological interactions at the molecular scale to create smart implants, responsive drug delivery devices, and regenerative tissue scaffolds. This merging not only increases mechanical and biological compatibility but also encourages the development of multifunctional devices to monitor in real time, to treat selectively, and to exhibit bio responsive behaviour. Examples ranging from 3D-bioprinted organs to nanoengineered scaffolds and smart diagnostic biosensors show the ability to solve persistent organ transplantation, cancer therapy, and chronic disease management challenges. In addition, breakthroughs such as 4D printing and AI-driven nano-bio fabrication will be pushing the boundaries further by creating patient-driven, self-adaptive therapeutic platforms. But still, large technical, regulatory, and ethical hurdles have to be crossed in order to integrate on a large scale in a clinical manner. Nevertheless, synergistic convergence of nanotechnology and additive manufacturing bodes well for a shift toward highly personalized, predictive, and effective medical treatments. This review discusses the revolutionary contribution of 3D printing nanotechnology in reframing the future of medicine with focus on the pressing need for an interdisciplinary team approach to realize its full capability. The epoch of tailoring personalized therapies to the molecular level is no longer an elusive vision but a swiftly realising expectation capable of radically redefining the delivery and outcomes of care at a worldwide scale.</div></div>","PeriodicalId":37770,"journal":{"name":"Bioprinting","volume":"50 ","pages":"Article e00430"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioprinting","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405886625000466","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Computer Science","Score":null,"Total":0}
引用次数: 0
Abstract
The combination of 3D printing and nanotechnology is remodeling the field of biomedical innovation, opening up unprecedented levels of precision, personalization, and function in health care. 3D printing provides the capacity to print complex, patient-specific constructs, and nanotechnology extends this with dynamic biological interactions at the molecular scale to create smart implants, responsive drug delivery devices, and regenerative tissue scaffolds. This merging not only increases mechanical and biological compatibility but also encourages the development of multifunctional devices to monitor in real time, to treat selectively, and to exhibit bio responsive behaviour. Examples ranging from 3D-bioprinted organs to nanoengineered scaffolds and smart diagnostic biosensors show the ability to solve persistent organ transplantation, cancer therapy, and chronic disease management challenges. In addition, breakthroughs such as 4D printing and AI-driven nano-bio fabrication will be pushing the boundaries further by creating patient-driven, self-adaptive therapeutic platforms. But still, large technical, regulatory, and ethical hurdles have to be crossed in order to integrate on a large scale in a clinical manner. Nevertheless, synergistic convergence of nanotechnology and additive manufacturing bodes well for a shift toward highly personalized, predictive, and effective medical treatments. This review discusses the revolutionary contribution of 3D printing nanotechnology in reframing the future of medicine with focus on the pressing need for an interdisciplinary team approach to realize its full capability. The epoch of tailoring personalized therapies to the molecular level is no longer an elusive vision but a swiftly realising expectation capable of radically redefining the delivery and outcomes of care at a worldwide scale.
期刊介绍:
Bioprinting is a broad-spectrum, multidisciplinary journal that covers all aspects of 3D fabrication technology involving biological tissues, organs and cells for medical and biotechnology applications. Topics covered include nanomaterials, biomaterials, scaffolds, 3D printing technology, imaging and CAD/CAM software and hardware, post-printing bioreactor maturation, cell and biological factor patterning, biofabrication, tissue engineering and other applications of 3D bioprinting technology. Bioprinting publishes research reports describing novel results with high clinical significance in all areas of 3D bioprinting research. Bioprinting issues contain a wide variety of review and analysis articles covering topics relevant to 3D bioprinting ranging from basic biological, material and technical advances to pre-clinical and clinical applications of 3D bioprinting.