Recurrent extrahepatic papillary cholangiocarcinoma with CCNE1 amplification, TP53 mutation and CNS involvement a capecitabine exceptional response case report
Veronica Salais Michaus , Javier Cervantes-Bojalil , José O. Navarro-Fernández , Edith A. Fernandez-Figueroa , Roberto Herrera-Goepfert , Maria Fernanda Tejada-Pineda , Erika Ruiz-Garcia
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Abstract
Cholangiocarcinoma (CCA) is a heterogeneous disease; the incidence of brain metastases from CCA ranges from 0.15 % to 1.4 %. We present the case of a 50-year-old woman with recurrent extrahepatic cholangiocarcinoma involving the central nervous system (CNS) and improvement in overall survival (OS). Next-Generation Sequencing (NGS) was performed, revealing CCNE1 amplification and a TP53 mutation.
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