Retraction Note: Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5– implications for dementia with lewy bodies

Abstract

Retraction Note

The Editorial team has retracted this article.

After publication, concerns were raised regarding some of the data presented in the figures. Specifically:

• Panels Non tg and APP tg in the second row of Fig. 5A appear to overlap;

• Panels Non tg in the third rows of Fig. 6B and D appear to overlap;

• Panels APP tg and alpha-syn tg in the first row of Fig. 7D appear to overlap;

• Panels Non-tg in the second rows of Fig. 7B and D appear to overlap;

• Panels APP tg and alpha-syn tg in the third row of Fig. 7D appear to overlap;

• Some blots in Fig. 9c appear to have similar bands between the two LV-control groups (vehicle and Aβ1–42).

The authors have stated that these errors occurred during figure preparation. However, due to the number of concerns, the Editors-in-Chief no longer have confidence in the presented data.

Cassia R Overk and Eliezer Masliah disagree with this retraction. The other authors have not responded to any correspondence from the editor or publisher about this retraction.

Authors and Affiliations

1. Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA

   Cassia R Overk, Anna Cartier, Gideon Shaked, Edward Rockenstein, Kiren Ubhi, Brian Spencer, Christina Patrick, Paula Desplats & Eliezer Masliah

2. Neuropore Therapies, Inc, San Diego, CA, 92121, USA

   Diana L Price

3. Department of Pathology, University of California, San Diego, La Jolla, CA, USA

   Eliezer Masliah

Authors

1. Cassia R OverkView author publications

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2. Anna CartierView author publications

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3. Gideon ShakedView author publications

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4. Edward RockensteinView author publications

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5. Kiren UbhiView author publications

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6. Brian SpencerView author publications

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7. Diana L PriceView author publications

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8. Christina PatrickView author publications

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9. Paula DesplatsView author publications

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10. Eliezer MasliahView author publications

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Corresponding author

Correspondence to Eliezer Masliah.

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Cite this article

Overk, C.R., Cartier, A., Shaked, G. et al. Retraction Note: Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5– implications for dementia with lewy bodies. Mol Neurodegeneration 20, 87 (2025). https://doi.org/10.1186/s13024-025-00881-6

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• Published: 05 August 2025

• DOI: https://doi.org/10.1186/s13024-025-00881-6

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