Skeletal editing of pyridines to aryldialdehydes.

IF 15.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Communications Pub Date : 2025-08-04 DOI:10.1038/s41467-025-62627-8

Meixin Yan,Yonglin Shi,Cong Lv,Shunyao Huang,Shun Li,Dexi Yang,Jiangui Zhao,Zhishan Su,Weidong Jiang,Weichao Xue,Jiaqi Xu,Xueli Zheng,Ruixiang Li,Hua Chen,Haiyan Fu

引用次数: 0

Abstract

Electron-deficient nitrogen-containing aromatic heterocycles, particularly pyridine derivatives, can be converted into all-carbon aromatic frameworks via the ANRORC (Addition of Nucleophile, Ring-Opening, and Ring-Closing) skeletal editing process, providing a convenient tool for molecular diversification. However, reported methods are mainly limited to nucleophilic modification of ring-opening species. Herein, we report a distinct electrophilic modification method, smoothly converting pyridines into arene-1,3-dialdehydes or naphthalene-1,3-dialdehydes.

查看原文本刊更多论文

吡啶到芳基二醛的骨架编辑。

缺乏电子的含氮芳香杂环化合物，特别是吡啶衍生物，可以通过ANRORC （Addition of Nucleophile, open - ring, and close - ring）骨架编辑过程转化为全碳芳香框架，为分子多样化提供了方便的工具。然而，目前报道的方法主要局限于开环物质的亲核修饰。在此，我们报道了一种独特的亲电修饰方法，可以将吡啶顺利转化为芳烃-1,3-二醛或萘-1,3-二醛。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nature Communications Biological Science Disciplines-

CiteScore

24.90

自引率

2.40%

发文量

6928

审稿时长

3.7 months

期刊介绍： Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.